Evidence map›Paper›PMID 34851763›Full record

ArticleThe Journal of international medical research2021

Mutation analysis of a 10-gene panel for colorectal cancer in Huizhou, Guangdong Province of China.

Jun Li, Aihua Sun, Guofang Zhong, Ying He, Hailin Xiong, Xia Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun LiDepartment of Medical Oncology, Huizhou First Hospital, Huizhou, Guangdong, China.
Aihua SunDepartment of Medical Oncology, Huizhou Municipal Center Hospital, Huizhou, Guangdong, China.
Guofang ZhongDepartment of Medical Oncology, Huizhou Municipal Center Hospital, Huizhou, Guangdong, China.
Ying HeDepartment of Medical Oncology, Huizhou Municipal Center Hospital, Huizhou, Guangdong, China.
Hailin XiongDepartment of Medical Oncology, Huizhou Municipal Center Hospital, Huizhou, Guangdong, China.
Xia YuanDepartment of Medical Oncology, Huizhou First Hospital, Huizhou, Guangdong, China.ORCID https://orcid.org/0000-0003-4371-2529
Huizhou Central People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the type and frequency of mutations in 10 genes in 85 colorectal cancer (CRC) patients in Huizhou and the guiding significance of targeted drug use.

methodsThe 10-gene panel next-generation sequencing (NGS) was used to assess genetic variants in 85 CRC patients from the Huizhou area combined with clinical information for a comprehensive analysis.

resultsUpon initial mutation testing, 68% (58/85) were positive. The mutation frequencies of these genes, including

conclusionGene mutations detected by a 10-gene panel were useful for targeting therapy of CRC in Huizhou.

Indexed as

Colorectal NeoplasmsProto-Oncogene Proteins B-rafCetuximabDNA Mutational AnalysisHumansMutationProto-Oncogene Proteins p21(ras)CetuximabProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Colorectal cancergene panelHuizhoumutationnext-generation sequencingtargeted therapy

Identifiers

PMID34851763
PMCPMC8647259
OpenAlexW3217131547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.