Evidence map›Paper›PMID 34851757›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults.

Pieter T Deckers, Alex A Bhogal, Mathijs Bj Dijsselhof, Carlos C Faraco, Peiying Liu, Hanzhang Lu, Manus J Donahue, Jeroen Cw Siero

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Interface focus · 2025
    Article
  4. Review
  5. Review
  6. Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Pieter T DeckersDepartment of Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0001-5476-547X
Alex A BhogalDepartment of Radiology, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0003-3211-1760
Mathijs Bj DijsselhofDepartment of Radiology, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0001-6005-3110
Carlos C FaracoRadiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Manus J DonahueRadiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeroen Cw SieroDepartment of Radiology, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0001-5079-2868
University Medical Center Utrecht · NLJohns Hopkins University · USVanderbilt University Medical Center · US

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Development and validation of empirical models of the neuronal population activity underlying non-invasive human brain measurementsR01MH111417 · NIMH · UNIVERSITY MEDICAL CENTER UTRECHT · PI DEVINSKY, ORRIN, DIJKHUIZEN, RICK M · 2016 to 2020
$4.4M
NIBIB NIH HHS P41 EB031771NIMH NIH HHS R01 MH111417
6 · The paper itself

Abstract

Blood oxygenation level-dependent (BOLD) or arterial spin labeling (ASL) MRI with hypercapnic stimuli allow for measuring cerebrovascular reactivity (CVR). Hypercapnic stimuli are also employed in calibrated BOLD functional MRI for quantifying neuronally-evoked changes in cerebral oxygen metabolism (CMRO

Indexed as

Carbon DioxideHyperoxiaAdultBrainCerebrovascular CirculationHemodynamicsHumansHypercapniaMagnetic Resonance ImagingOxygenOxygen ConsumptionCarbon DioxideOxygenCarbogencerebral metabolic rate of oxygencerebral venous oxygenationhypercapniahyperoxia

Identifiers

PMID34851757
PMCPMC9014679
OpenAlexW3216826809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.