ArticleScience translational medicine2021
AD-linked R47H-
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 3 pooled it
8.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis.Nature communications · 2025Pooled it
- The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases.Journal of advanced research · 2025Pooled it
- Association of soluble TREM2 with Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Article
- Single-cell transcriptomics of human brain disorders.Molecular psychiatry · 2026Review
- Targeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females.Research square · 2026Article
- TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell communication and signaling : CCS · 2026Review
- Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.BMC medicine · 2026Review
- Increased circulating TREM2Brain, behavior, & immunity - health · 2026Article
- Protective mutations associated with APOE in Alzheimer's disease.Molecular psychiatry · 2026Review
- A Multi-Context Regulome-Wide Association Atlas for Genetic Studies of Aging Brain Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.Acta neuropathologica · 2026Article
- Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging.Journal of molecular biology · 2026Review
- Autophagy-Neuroinflammation Axis in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential.Cells · 2026Review
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells.Stem cell reports · 2026Review
- Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation.Trends in neurosciences · 2026Review
- Parkinson's disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses.NPJ Parkinson's disease · 2026Review
- The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function.Neuron · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 12 institutions in 3 countries.
Faten A SayedNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-3992-4668
Lay KodamaNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-8419-8445
Li FanHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0003-1780-6919
Gillian K CarlingHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-1504-1716
Joe C UdeochuHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
David LeGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.ORCID 0000-0002-6526-335X
Qingyun LiDepartment of Neuroscience and Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-3457-5967
Lu ZhouDepartment of Neuroscience and Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Man Ying WongHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
Rose HorowitzHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0002-8177-941X
Pearly YeHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
Hansruedi MathysThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-5842-5245
Minghui WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA.ORCID 0000-0001-9171-4962
Xiang NiuTri-Institutional Computational Biology and Medicine Program, Weill Cornell Medical College, NY 10065, USA.ORCID 0000-0001-7689-0941
Linas MazutisComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-5552-6427
Xueqiao JiangThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xueting WangHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-6172-7148
Fuying GaoDepartments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Matthew BrendelInstitute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0003-3417-4597
Maria TelpoukhovskaiaGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.ORCID 0000-0002-5237-4042
Tara E TracyGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.ORCID 0000-0003-3356-4091
Georgia FrostChemical Biology Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10065, USA.ORCID 0000-0002-7658-954X
Yungui ZhouGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.
Yaqiao LiGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.
Yue QiuDepartment of Computer Science, Hunter College, and The Graduate Center, The City University of New York, New York, NY 10065, USA.ORCID 0000-0001-9692-1290
Zuolin ChengBradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 24061, USA.ORCID 0000-0002-5197-5874
Guoqiang YuBradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 24061, USA.ORCID 0000-0002-6743-7413
John HardyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1E 6BT, UK.ORCID 0000-0002-3122-0423
Giovanni CoppolaDepartments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2105-1061
Fei WangDepartment of Population Health Sciences, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0001-9459-9461
Michael A DeTureMayo Clinic, Jacksonville, Florida 32224, USA.ORCID 0000-0002-4363-1262
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA.ORCID 0000-0002-9549-5653
Lei XieChemical Biology Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10065, USA.ORCID 0000-0001-9051-2111
John Q TrajnowskiCenter for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-9239-8794
Virginia M Y LeeCenter for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0003-3536-6902
Shiaoching GongHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
Subhash C SinhaHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.ORCID 0000-0001-8916-5677
Dennis W DicksonMayo Clinic, Jacksonville, Florida 32224, USA.ORCID 0000-0001-7189-7917
Wenjie LuoHelen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
Li GanGladstone Institute of Neurological Disease, San Francisco, CA 94107, USA.ORCID 0000-0003-4600-275X
Cornell University · USGladstone Institutes · USIcahn School of Medicine at Mount Sinai · USInstitute for Neurodegenerative Disorders · USMassachusetts Institute of Technology · USUniversity of California, Los Angeles · USVirginia Tech · USWashington University in St. Louis · USWinnMed · USMemorial Sloan Kettering Cancer Center · USNational Hospital for Neurology and Neurosurgery · GBThe Graduate Center, CUNY · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2013 to 2022
$26.0MProject 3: Autophagy dysfunction and neuronal activity in FTDU54NS100717 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CUERVO, ANA MARIA · 2016 to 2020
$10.8MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MDrug repurposing for Alzheimer's disease using structural systems pharmacology.R01AG057555 · NIA · NORTHEASTERN UNIVERSITY · PI Lei Xie · 2018 to 2026
$6.7MIntegrative Network Modeling of Cognitive Resilience to Alzheimer's DiseaseR01AG057907 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, HAROUTUNIAN, VAHRAM · 2017 to 2021
$6.3MDecoding Astrocyte Signaling in Neural Circuitry with Novel Computational Modeling and Analytical ToolsR01MH110504 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YUE WANG · 2017 to 2026
$6.1MMolecular Characterization and Validation of Gender Differences in Alzheimers Disease PathogenesisRF1AG054014 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, ZHANG, BIN · 2016 to 2016
$4.2MTranscriptional Control of Neuroinflammation in Alzheimer's DiseaseR01AG072562 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, ZHOU, MING-MING · 2021 to 2025
$4.2MSYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)RF1AG059319 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2018 to 2018
$4.2MMaladaptive antiviral pathways in Alzheimer's diseaseR01AG072758 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAN, LI · 2021 to 2025
$4.1MDepartment of HealthMedical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L501542/1Medical Research Council MR/N026004/1NCI NIH HHS P30 CA008748NIA NIH HHS F30 AG062043NIA NIH HHS F31 AG058505NIA NIH HHS K01 AG057862NIA NIH HHS R01 AG051390NIA NIH HHS R01 AG054214NIA NIH HHS R01 AG057555NIA NIH HHS R01 AG057907NIA NIH HHS R01 AG064239NIA NIH HHS R01 AG072562NIA NIH HHS R01 AG072758NIA NIH HHS RF1 AG054014NIA NIH HHS RF1 AG057440NIA NIH HHS RF1 AG059319NIA NIH HHS U01 AG046170NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM007618NIMH NIH HHS R01 MH110504NINDS NIH HHS U54 NS100717Parkinson's UK G-0907Parkinson's UK G-1307Wellcome TrustWellcome Trust 202903/Z/16/Z
Abstract
The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (
Indexed as
Alzheimer DiseaseMicrogliaAnimalsBrainFemaleHumansMembrane GlycoproteinsMiceMutationProto-Oncogene Proteins c-aktReceptors, ImmunologicMembrane GlycoproteinsProto-Oncogene Proteins c-aktReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.