Evidence map›Paper›PMID 34851664›Full record

ArticleScience advances2021

Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression.

Xiling Li, Chun Chien, Yifu Han, Zihan Sun, Xun Chen, Dion Dickman

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Glutamate receptor composition atbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Soma CaCurrent biology : CB · 2026
    Article
  7. Genetic dissection of theMolecular biology of the cell · 2025
    Article
  8. Article
  9. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
  12. Molecular organization of central cholinergic synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. CaSTAR protocols · 2024
    Article
  17. Article
  18. Article
  19. Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiling LiDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-2727-244X
Chun ChienDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0003-0132-8457
Yifu HanDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-1201-654X
Zihan SunDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0001-5576-6845
Xun ChenDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0001-6871-2758
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0003-1884-284X
University of Southern California · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS111414
6 · The paper itself

Abstract

Homeostatic modulation of presynaptic neurotransmitter release is a fundamental form of plasticity that stabilizes neural activity, where presynaptic homeostatic depression (PHD) can adaptively diminish synaptic strength. PHD has been proposed to operate through an autocrine mechanism to homeostatically depress release probability in response to excess glutamate release at the

Identifiers

PMID34851664
PMCPMC8635443
OpenAlexW3216127559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.