Evidence map›Paper›PMID 34851661›Full record

ArticleScience advances2021

Heart neurons use clock genes to control myocyte proliferation.

Emmanouil Tampakakis, Harshi Gangrade, Stephanie Glavaris, Myo Htet, Sean Murphy, Brian Leei Lin, Ting Liu, Amir Saberi, Matthew Miyamoto, William Kowalski and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Emmanouil TampakakisDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-3143-6459
Harshi GangradeDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Stephanie GlavarisDivision of Paediatric Oncology, Department of Paediatrics, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-8695-052X
Myo HtetDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7653-1658
Sean MurphyDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-1960-2194
Brian Leei LinDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-0800-7103
Ting LiuDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-8304-5751
Amir SaberiDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Matthew MiyamotoDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-2140-6769
William KowalskiLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yoh-Suke MukouyamaLaboratory of Stem Cell and Neuro-Vascular Biology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9084-4922
Gabsang LeeInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5052-5927
Liliana MinichielloDepartment of Pharmacology, Oxford University, Oxford, UK.ORCID 0000-0002-4246-4765
Chulan KwonDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-4924-2778
Johns Hopkins University · USNational Institutes of Health · USUniversity of Oxford · GB

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Transcriptomic Entropy to Quantify Maturation of PSC-Derived CardiomyocytesR01HL156947 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIM, DEOK-HO, KWON, CHULAN · 2021 to 2024
$2.3M
Regulation of Cardiac Progenitor MaintenanceR01HD086026 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KWON, CHULAN · 2016 to 2020
$1.6M
Engineering a power switch to study the contribution of stem cell-derived cardiomyocytes on heart regenerationK08HL145135 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TAMPAKAKIS, EMMANOUIL · 2019 to 2023
$859k
NHLBI NIH HHS K08 HL145135NHLBI NIH HHS R01 HL156947NHLBI NIH HHS T32 HL007227NICHD NIH HHS R01 HD086026
6 · The paper itself

Abstract

Neurons can regulate the development, pathogenesis, and regeneration of target organs. However, the role of neurons during heart development and regeneration remains unclear. We genetically inhibited sympathetic innervation in vivo, which resulted in heart enlargement with an increase in cardiomyocyte number. Transcriptomic and protein analysis showed down-regulation of the two clock gene homologs

Identifiers

PMID34851661
PMCPMC8635446
OpenAlexW3215193234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.