Evidence map›Paper›PMID 34851367›Full record

ArticleJAMA psychiatry2022

Deletion of Loss-of-Function-Intolerant Genes and Risk of 5 Psychiatric Disorders.

Michael Wainberg, Daniele Merico, Guillaume Huguet, Mehdi Zarrei, Sebastien Jacquemont, Stephen W Scherer, Shreejoy J Tripathy

Abstract read
In one paragraph

Article in JAMA psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Subcortical brain alterations in carriers of genomic copy number variants.medRxiv : the preprint server for health sciences · 2023
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael WainbergKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Daniele MericoDeep Genomics Inc, Toronto, Ontario, Canada.
Guillaume HuguetDepartment of Pediatrics, Université de Montréal, Montreal, Quebec, Canada.
Mehdi ZarreiThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sebastien JacquemontDepartment of Pediatrics, Université de Montréal, Montreal, Quebec, Canada.
Stephen W SchererThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Shreejoy J TripathyKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Funding

Large-Scale Evaluation of the Effect of Rare Genetic Variants on Psychiatric Symptoms and Cognitive AbilityU01MH119690 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ALMASY, LAURA A., GLAHN, DAVID C · 2019 to 2023
$5.9M
6/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders.U01MH119739 · NIMH · SAINTE-JUSTINE UNIVERSITY HOSPITAL CTR · PI JACQUEMONT, SEBASTIEN · 2020 to 2024
$527k
CIHR NGN-171423NIMH NIH HHS U01 MH119690NIMH NIH HHS U01 MH119739
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene DeletionHumansLoss of Function MutationMental DisordersOdds RatioUnited Kingdom

Identifiers

PMID34851367
PMCPMC8733829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.