Evidence map›Paper›PMID 34851162›Full record

ArticleMicrobiology spectrum2021

Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity.

Hitoshi Kawasuji, Yoshitomo Morinaga, Hideki Tani, Yumiko Saga, Makito Kaneda, Yushi Murai, Akitoshi Ueno, Yuki Miyajima, Yasutaka Fukui, Kentaro Nagaoka and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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  10. Effectiveness of the third dose of BNT162b2 vaccine on neutralizing Omicron variant in the Japanese population.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Hitoshi KawasujiDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Yoshitomo MorinagaDepartment of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.ORCID 0000-0002-3827-6411
Hideki TaniDepartment of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.ORCID 0000-0002-6309-277X
Yumiko SagaDepartment of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Makito KanedaDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Yushi MuraiDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Akitoshi UenoDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Yuki MiyajimaDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Yasutaka FukuiDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Kentaro NagaokaDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Chikako OnoLaboratory of Virus Control, Center for Infectious Disease Education and Research (CiDER), Osaka Universitygrid.136593.b, Osaka, Japan.
Yoshiharu MatsuuraLaboratory of Virus Control, Center for Infectious Disease Education and Research (CiDER), Osaka Universitygrid.136593.b, Osaka, Japan.
Hideki NiimiClinical and Research Center for Infectious Diseases, Toyama University Hospitalgrid.452851.f, Toyama, Japan.
Yoshihiro YamamotoDepartment of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
University of Toyama · JPToyama University Hospital · JPThe University of Osaka · JPToyama Institute of Health · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP20he0622035University of Toyama () The Research Funding Grant by the president
6 · The paper itself

Abstract

Vaccines against severe acute respiratory syndrome coronavirus-2 have been introduced. To investigate the relationship between vaccine-induced humoral immunity and patient age, we measured antibody levels and neutralization in vaccinated sera. Sera from 13 to 17 days after the second dose of the BNT162b2 vaccine were collected from health care workers at the University of Toyama (

Indexed as

ImmunityAdultAgedAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19Cross ReactionsFemaleHumansImmunity, HumoralMaleMiddle AgedmRNA VaccinesNeutralization TestsSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralBNT162 VaccinemRNA VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2BNT162b2neutralizing antibodiesreceptor-binding domainSARS-CoV-2variants

Identifiers

PMID34851162
PMCPMC8635122
OpenAlexW3217785789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.