Evidence map›Paper›PMID 34851145›Full record

ArticleJournal of virology2022

Mooring Stone-Like Arg

Can Yue, Wangzhen Xiang, Xiaowen Huang, Yuan Sun, Jin Xiao, Kefang Liu, Zeyu Sun, Peiwen Qiao, Hongmei Li, Jingxuan Gan and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Can Yue *Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Wangzhen Xiang *Key Laboratory of Veterinary Bioproduction and Chemical Medicine of the Ministry of Agriculture, Engineering and Technology Research Center for Beijing Veterinary Peptide Vaccine Design and Preparation, Zhongmu Institute of China Animal Husbandry Industry, Co., Ltd., Beijing, China.
Xiaowen Huang *Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Yuan Sun *State Key Laboratory of Veterinary Biotechnology, National High-Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institutegrid.38587.31, Chinese Academy of Agricultural Sciences, Harbin, China.
Jin XiaoKey Laboratory of Veterinary Bioproduction and Chemical Medicine of the Ministry of Agriculture, Engineering and Technology Research Center for Beijing Veterinary Peptide Vaccine Design and Preparation, Zhongmu Institute of China Animal Husbandry Industry, Co., Ltd., Beijing, China.
Kefang LiuCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Zeyu SunState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Peiwen QiaoNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Hongmei LiNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Jingxuan GanSchool of Engineering, University of Guelph, Guelph, Ontario, Canada.
Limin BaKey Laboratory of Veterinary Bioproduction and Chemical Medicine of the Ministry of Agriculture, Engineering and Technology Research Center for Beijing Veterinary Peptide Vaccine Design and Preparation, Zhongmu Institute of China Animal Husbandry Industry, Co., Ltd., Beijing, China.
Yan ChaiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Jianxun QiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Peipei LiuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Peng QiKey Laboratory of Veterinary Bioproduction and Chemical Medicine of the Ministry of Agriculture, Engineering and Technology Research Center for Beijing Veterinary Peptide Vaccine Design and Preparation, Zhongmu Institute of China Animal Husbandry Industry, Co., Ltd., Beijing, China.
Yingze ZhaoNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Yongfeng LiState Key Laboratory of Veterinary Biotechnology, National High-Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institutegrid.38587.31, Chinese Academy of Agricultural Sciences, Harbin, China.
Hua-Ji QiuState Key Laboratory of Veterinary Biotechnology, National High-Containment Facilities for Animal Disease Control and Prevention, Harbin Veterinary Research Institutegrid.38587.31, Chinese Academy of Agricultural Sciences, Harbin, China.ORCID 0000-0003-4880-5687
George F GaoSavaid Medical School, University of Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-3869-615X
Guolan GaoSavaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
William J LiuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.ORCID 0000-0003-3605-4070
Chinese Center For Disease Control and Prevention · CNChinese Academy of Agricultural Sciences · CNChinese Academy of Sciences · CNState Key Laboratory of Diagnosis and Treatment of Infectious DiseasesUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), which is a devastating pig disease threatening the global pork industry. However, currently, no commercial vaccines are available. During the pig immune response, major histocompatibility complex class I (MHC-I) molecules select viral peptide epitopes and present them to host cytotoxic T lymphocytes, thereby playing critical roles in eliminating viral infections. Here, we screened peptides derived from ASFV and determined the molecular basis of ASFV-derived peptides presented by the swine leukocyte antigen 1*0101 (SLA-1*0101). We found that peptide binding in SLA-1*0101 differs from the traditional mammalian binding patterns. Unlike the typical B and F pockets used by the common MHC-I molecule, SLA-1*0101 uses the D and F pockets as major peptide anchor pockets. Furthermore, the conformationally stable Arg

Indexed as

African Swine Fever VirusAnimalsAntigen PresentationArginineBinding SitesCapsid ProteinsEpitopes, T-LymphocyteFoot-and-Mouth Disease VirusHistocompatibility Antigens Class ILymphocyte ActivationPeptidesProtein BindingProtein ConformationSwineT-Lymphocytes, CytotoxicArgininecapsid protein p72, African swine fever virusCapsid ProteinsEpitopes, T-LymphocyteHistocompatibility Antigens Class IPeptidesswine leukocyte antigenAfrican swine fever virusepitopeSLA-1structureT cells

Identifiers

PMID34851145
PMCPMC8865485
OpenAlexW3214856922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.