Evidence map›Paper›PMID 34851045›Full record

ArticlePhysiological reports2021

Application of oxygen saturation variability analysis for the detection of exacerbation in individuals with COPD: A proof-of-concept study.

Ahmed Al Rajeh, Amar S Bhogal, Yunkai Zhang, Joseph T Costello, John R Hurst, Ali R Mani

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Physiological signal entropy in patients with chronic respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  4. Decrypting network physiology for clinical practice.Frontiers in network physiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ahmed Al RajehUCL Respiratory, Royal Free Campus, Division of Medicine, University College London, London, UK.
Amar S BhogalNetwork Physiology Laboratory, Division of Medicine, UCL, London, UK.
Yunkai ZhangNetwork Physiology Laboratory, Division of Medicine, UCL, London, UK.
Joseph T CostelloExtreme Environment Laboratory, School of Sport, Health and Exercise Science, University of Portsmouth, Portsmouth, UK.
John R HurstUCL Respiratory, Royal Free Campus, Division of Medicine, University College London, London, UK.
Ali R ManiNetwork Physiology Laboratory, Division of Medicine, UCL, London, UK.ORCID 0000-0003-0830-2022
University College London · GBThe Royal Free Hospital · GBUniversity of Portsmouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with chronic obstructive pulmonary disease (COPD) commonly experience exacerbations, which may require hospital admission. Early detection of exacerbations, and therefore early treatment, could be crucial in preventing admission and improving outcomes. Our previous research has demonstrated that the pattern analysis of peripheral oxygen saturation (S

methodsOvernight pulse oximetry data from 11 individuals with COPD, who exhibited exacerbation after a period of stable disease, were examined. Stable phase recordings were conducted overnight and one night prior to exacerbation recordings were also analyzed. Pattern analysis of S

resultsS

conclusionAlterations in S

Indexed as

AgedAged, 80 and overDisease ProgressionFemaleHumansHypoxiaMaleMiddle AgedOximetryOxygen SaturationPilot ProjectsPulmonary Disease, Chronic Obstructiveentropyphysiological measurementPulse OximetryrespiratorySpO2

Identifiers

PMID34851045
PMCPMC8634631
OpenAlexW3217770848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.