ArticleEuropean eating disorders review : the journal of the Eating Disorders Association2022
The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa-A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial.
Article in European eating disorders review : the journal of the Eating Disorders Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Adverse event monitoring, assessment, and reporting in nutraceutical and phytoceutical trials for pediatric neuropsychiatric conditions: A systematic review.Journal of psychopharmacology (Oxford, England) · 2025Pooled it
- The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults-Systematic Review.International journal of molecular sciences · 2023Pooled it
- Refeeding the Gut in Anorexia Nervosa: Microbiome, Nutritional Rehabilitation and Dietetic Care.Nutrients · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
- The Influence of Omega-3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model.The International journal of eating disorders · 2026Article
- The Pediatric Microbiota-Gut-Brain Axis: Implications for Neuropsychiatric Development and Intervention.Children (Basel, Switzerland) · 2025Review
- Exploring the Link Between the Gut Microbiota and Epigenetic Factors in Anorexia Nervosa.Brain and behavior · 2025Review
- Gut Microbiota in Women with Eating Disorders: A New Frontier in Pathophysiology and Treatment.Nutrients · 2025Review
- Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies.The Psychiatric clinics of North America · 2025Review
- Chronic starvation induces microglial cell depletion in an activity-based anorexia model.Scientific reports · 2025Article
- AlleviatingAnimals : an open access journal from MDPI · 2025Article
- Progress in Probiotic Science: Prospects of Functional Probiotic-Based Foods and Beverages.International journal of food science · 2025Review
- [New aspects in etiology and treatment of adolescent anorexia nervosa-a postulated bio-psycho-social model and the impact of the COVID-19 pandemic].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024Review
- Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota.Frontiers in microbiology · 2024Article
- Gut-Associated Lymphatic Tissue in Food-Restricted Rats: Influence of Refeeding and Probiotic Supplementation.Microorganisms · 2023Article
- The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice.Nature microbiology · 2023Article
- A critical analysis of eating disorders and the gut microbiome.Journal of eating disorders · 2022Article
- Psychobiotics: the Influence of Gut Microbiota on the Gut-Brain Axis in Neurological Disorders.Journal of molecular neuroscience : MN · 2022Article
- Are the Effects of Malnutrition on the Gut Microbiota-Brain Axis the Core Pathologies of Anorexia Nervosa?Microorganisms · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveKnowledge on gut-brain interaction might help to develop new therapies for patients with anorexia nervosa (AN), as severe starvation-induced changes of the microbiome (MI) do not normalise with weight gain. We examine the effects of probiotics supplementation on the gut MI in patients with AN.
methodThis is a study protocol for a two-centre double-blind randomized-controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment-as-usual compared to placebo in 60 patients with AN (13-19 years). Moreover, 60 sex- and age-matched healthy controls are included in order to record development-related changes. Assessments are conducted at baseline, discharge, 6 and 12 months after baseline. Assessments include measures of body mass index, psychopathology (including eating-disorder-related psychopathology, depression and anxiety), neuropsychological measures, serum and stool analyses. We hypothesise that probiotic administration will have positive effects on the gut microbiota and the treatment of AN by improvement of weight gain, gastrointestinal complaints and psychopathology, and reduction of inflammatory processes compared to placebo.
conclusionsIf probiotics could help to normalise the MI composition, reduce inflammation and gastrointestinal discomfort and increase body weight, its administration would be a readily applicable additional component of multi-modal AN treatment.
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