ArticleSocial cognitive and affective neuroscience2022
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.
Article in Social cognitive and affective neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clarifying the role of Cortico-Cortical and Amygdalo-Cortical brain dysconnectivity associated with Conduct Problems.NeuroImage. Clinical · 2023Pooled it
- The role of functional emotion circuits in distinct dimensions of psychopathology in youth.Translational psychiatry · 2024Article
- Psychophysiological Factors Moderate Amygdala-Prefrontal Connectivity Linked to Perceived Peer Victimization and Depressive Symptoms in Preadolescent Migrant Children.Depression and anxiety · 2024Article
- Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity.Translational psychiatry · 2023Article
- Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.Biological psychiatry global open science · 2023Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Neurofunctional Correlates of Hostility in Adolescents With Externalizing Disorders: Implications for Clinical Assessment and Intervention.Basic and clinical neuroscienceArticle
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Authors and funding
6 authors.
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Abstract
Childhood maladaptive aggression is associated with disrupted functional connectivity within amygdala-prefrontal circuitry. In this study, neural correlates of childhood aggression were probed using the intrinsic connectivity distribution, a voxel-wise metric of global resting-state brain connectivity. This sample included 38 children with aggressive behavior (26 boys, 12 girls) ages 8-16 years and 21 healthy controls (14 boys, 6 girls) matched for age and IQ. Functional MRI data were acquired during resting state, and differential patterns of intrinsic functional connectivity were tested in a priori regions of interest implicated in the pathophysiology of aggressive behavior. Next, correlational analyses tested for associations between functional connectivity and severity of aggression measured by the Reactive-Proactive Aggression Questionnaire in children with aggression. Children with aggressive behavior showed increased global connectivity in the bilateral amygdala relative to controls. Greater severity of aggressive behavior was associated with decreasing global connectivity in the dorsal anterior cingulate and ventromedial prefrontal cortex. Follow-up seed analysis revealed that aggression was also positively correlated with left amygdala connectivity with the dorsal anterior cingulate, ventromedial and dorsolateral prefrontal cortical regions. These results highlight the potential role of connectivity of the amygdala and medial prefrontal and anterior cingulate cortices in modulating the severity of aggressive behavior in treatment-seeking children.
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