ArticleAmerican journal of epidemiology2022
Testing Black-White Disparities in Biological Aging Among Older Adults in the United States: Analysis of DNA-Methylation and Blood-Chemistry Methods.
Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.
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Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Social determinants of health and epigenetic clocks: a systematic review and meta-analysis of 140 studies.Nature human behaviour · 2026Pooled it
- Molecular Biomarkers for Early Detection of Alzheimer's Disease and the Complementary Role of Engineered Nanomaterials: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Pooled it
- Effects of a randomized controlled trial of unconditional cash transfers on epigenetic measures of ageing and cognition in children and mothers.Nature human behaviour · 2026Trial
- How education gets under the skin: Pathways linking educational advantage to slower biological aging.Social science & medicine (1982) · 2026Article
- Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Accelerated biological aging, genetic susceptibility, and the risk of peripheral arterial disease: Evidence from the UK Biobank cohort study.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults.GeroScience · 2026Article
- Co-Expressed MicroRNAs Identify Potential Mechanisms Underlying Risk for Multimorbid Depression and Type 2 Diabetes in Midlife Women.bioRxiv : the preprint server for biology · 2026Article
- Phenotypic age acceleration and all-cause and cardiovascular mortality among U.S. adults at risk for heart failure.American heart journal plus : cardiology research and practice · 2026Article
- Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults.GeroScience · 2026Article
- Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank.Stroke and vascular neurology · 2026Article
- Phenotypic age acceleration and early-onset lung cancer: a case-control and prognostic cohort study involving multiple clinical centres with validation in the UK Biobank.EBioMedicine · 2026Article
- Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005-2010 and 2015-2016.GeoHealth · 2026Article
- Plasma proteomics identify novel biomarkers and dynamic patterns of biological aging.Journal of advanced research · 2026Article
- Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank.Frontiers in endocrinology · 2026Article
- Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects.Biology of sport · 2026Article
- Accelerated Biological Aging, Genetic Predisposition, and Incident Valvular Heart Disease.JACC. Asia · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Construction and validation of a novel nutrient-based index for risk of aging using an interpretable machine learning framework: results from two population-based studies.Nutrition journal · 2025Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Biological aging is a proposed mechanism through which social determinants drive health disparities. We conducted proof-of-concept testing of 8 DNA-methylation (DNAm) and blood-chemistry quantifications of biological aging as mediators of disparities in healthspan between Black and White participants in the 2016 wave of the Health and Retirement Study (n = 9,005). We quantified biological aging from 4 DNAm "clocks" (Horvath, Hannum, PhenoAge, and GrimAge clock), a DNAm pace-of-aging measure (DunedinPoAm), and 3 blood-chemistry measures (PhenoAge, Klemera-Doubal method biological age, and homeostatic dysregulation). We quantified Black-White disparities in healthspan from cross-sectional and longitudinal data on physical performance tests, self-reported limitations in activities of daily living, and physician-diagnosed chronic diseases, self-rated health, and survival. DNAm and blood-chemistry quantifications of biological aging were moderately correlated (Pearson's r = 0.1-0.4). The GrimAge clock, DunedinPoAm, and all 3 blood-chemistry measures were associated with healthspan characteristics (e.g., mortality effect-size hazard ratios were 1.71-2.32 per standard deviation of biological aging) and showed evidence of more advanced/faster biological aging in Black participants than in White participants (Cohen's d = 0.4-0.5). These measures accounted for 13%-95% of Black-White differences in healthspan-related characteristics. Findings suggest that reducing disparities in biological aging can contribute to building health equity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.