ArticleMicrobiology (Reading, England)2021
Functional diversity increases the efficacy of phage combinations.
Article in Microbiology (Reading, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Systematic combinatorial optimization of three-phage cocktails against multidrug-resistantMicrobiology spectrum · 2026Article
- Phenotypic heterogeneity shapes phage resistance and cocktail efficacy inMicrobiology spectrum · 2026Article
- Towards modeling phage therapy.PLoS computational biology · 2026Article
- Steering the course: targeting and exploiting surface receptors in phage therapy.Journal of bacteriology · 2026Review
- Searching for the perfect match: can non-antibiotic antimicrobials improve bacteriophage performance?Frontiers in cellular and infection microbiology · 2026Review
- Quantitative phage-host interaction profiling supports the design of a broadly active phage cocktail against multidrug-resistantFrontiers in microbiology · 2026Article
- Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections.Nature microbiology · 2025Article
- Review
- The Japan-UK Synthetic Biology Conference, Spring 2025: Strengthening Global Links to Engineer Biology.ACS synthetic biology · 2025Article
- Harnessing phage consortia to mitigate the soil antibiotic resistome by targeting keystone taxa Streptomyces.Microbiome · 2025Article
- Multi-strain phage induced clearance of bacterial infections.PLoS computational biology · 2025Article
- Strain identity effects contribute more to Pseudomonas community functioning than strain interactions.The ISME journal · 2025Article
- Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025Review
- Multi-strain phage induced clearance of bacterial infections.bioRxiv : the preprint server for biology · 2024Article
- Phages enhance both phytopathogen density control and rhizosphere microbiome suppressiveness.mBio · 2024Article
- Combination of genetically diverse Pseudomonas phages enhances the cocktail efficiency against bacteria.Scientific reports · 2023Article
- The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy.iScience · 2023Review
- Comparison of bacterial suppression by phage cocktails, dual-receptor generalists, and coevolutionarily trained phages.Evolutionary applications · 2023Article
- A Phage Foundry Framework to Systematically Develop Viral Countermeasures to Combat Antibiotic-Resistant Bacterial Pathogens.iScience · 2022Review
- Phenotypic flux: The role of physiology in explaining the conundrum of bacterial persistence amid phage attack.Virus evolution · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phage therapy is a promising alternative to traditional antibiotics for treating bacterial infections. Such phage-based therapeutics typically contain multiple phages, but how the efficacy of phage combinations scales with phage richness, identity and functional traits is unclear. Here, we experimentally tested the efficacy of 827 unique phage combinations ranging in phage richness from one to 12 phages. The efficacy of phage combinations increased with phage richness. However, complementarity between functionally diverse phages allowed efficacy to be maximized at lower levels of phage richness in functionally diverse combinations. These findings suggest that phage functional diversity is the key property of effective phage combinations, enabling the design of simple but effective phage therapies that overcome the practical and regulatory hurdles that limit development of more diverse phage therapy cocktails.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.