Evidence map›Paper›PMID 34850640›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Diet-induced obesity in mice impairs host defense against

Peter Mancuso, Jeffrey L Curtis, Anne M Weitzel, Cameron A Griffin, Benjamin Bouchard, Christine M Freeman, Dave Bridges, Kanakadurga Singer

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  12. Host defense against the infection ofFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Peter MancusoDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-2559-7320
Jeffrey L CurtisGraduate Program in Immunology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-5191-4847
Anne M WeitzelDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Cameron A GriffinDivision of Pediatric Endocrinology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Benjamin BouchardDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Christine M FreemanGraduate Program in Immunology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-3548-8133
Dave BridgesDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-5334-972X
Kanakadurga SingerGraduate Program in Immunology, University of Michigan, Ann Arbor, Michigan.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
The Role of Androgens in Obesity Induced Meta-InflammationR01DK115583 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SINGER, KANAKADURGA · 2018 to 2022
$2.2M
Regulation of Lipid Storage by mTORC1R01DK107535 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BRIDGES, DAVE · 2016 to 2020
$1.7M
Mechanisms of hematopoietic stem cell activation in obesityK08DK101755 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SINGER, KANAKADURGA · 2015 to 2018
$644k
Regulatory T Cell Inhibition of Natural Killer Cells in COPDI01CX001553 · VA · VETERANS HEALTH ADMINISTRATION · PI Christine M Basmajian · 2017 to 2026
–
Modulation of Steroid Suppression by Alveolar Macrophage EfferocytosisI01CX000911 · VA · VETERANS HEALTH ADMINISTRATION · PI CURTIS, JEFFREY LOUIS · 2016 to 2020
–
Effect of Haemophilus influenzae infection on lung CD8+ T cells in COPDI01BX001389 · VA · VETERANS HEALTH ADMINISTRATION · PI BASMAJIAN, CHRISTINE M. · 2012 to 2014
–
BLRD VA I01 BX001389CSRD VA I01 CX000911CSRD VA I01 CX001553NIDDK NIH HHS K08 DK101755NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK107535NIDDK NIH HHS R01 DK115583
6 · The paper itself

Abstract

Obesity impairs host defense against

Indexed as

DietHost-Pathogen InteractionsAdipose Tissue, WhiteAdiposityAnimalsBacterial LoadBiological TransportBlood GlucoseBody WeightBone MarrowBronchoalveolar Lavage FluidCytokinesDeoxyglucoseDiet, High-FatGlucoseGlucose Transporter Type 1Blood GlucoseCytokinesDeoxyglucoseGlucoseGlucose Transporter Type 1Glucose Transporter Type 3RNA, Messengerbacterial pneumoniahost defenseKlebsiella pneumoniaelungneutrophilsobesity

Identifiers

PMID34850640
PMCPMC8794018
OpenAlexW3215717076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.