Evidence map›Paper›PMID 34850468›Full record

ArticleXenotransplantation2021

Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation.

David K C Cooper, Jeremy B Foote, Mariyam Javed, Huy Q Nguyen, Mohamed H Bikhet, Christophe Hansen-Estruch, David Ayares, Hidetaka Hara

Abstract readLetter
In one paragraph

Article in Xenotransplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. [Research and application progress for liver xenotransplantation].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  2. Review
  3. Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  4. The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  5. Article
  6. Article
  7. Milestones on the path to clinical pig organ xenotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Review
  8. Review
  9. Developments in kidney xenotransplantation.Frontiers in immunology · 2023
    Review
  10. Review
  11. Review
  12. The Long and Winding Road to Clinical Xenotransplantation: A Personal Journey.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2022
    Review
  13. Review
  14. Invited commentary.Xenotransplantation · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David K C CooperDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-8899-9431
Jeremy B FooteDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6621-6096
Mariyam JavedDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Huy Q NguyenDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mohamed H BikhetDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Christophe Hansen-EstruchDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0090-9877
David AyaresRevivicor, Blacksburg, Virginia, USA.
Hidetaka HaraDepartment of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-4179-7365

Funding

Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative SupplementP40OD024628 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WILLIAM D HOPKINS · 2017 to 2026
$15.7M
NIAID NIH HHS U19 AI090959NIH HHS P40 OD024628
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CD40 AntigensCD40 LigandGraft SurvivalTransplantation, HeterologousCD40 AntigensCD40 Ligand

Identifiers

PMID34850468
PMCPMC8712414

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.