Evidence map›Paper›PMID 34850364›Full record

ArticleJournal of endocrinological investigation2022

Screening for drugs potentially interfering with MCT8-mediated T

C Di Cosmo, G De Marco, P Agretti, E Ferrarini, A Dimida, P Falcetta, S Benvenga, P Vitti, M Tonacchera

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

C Di CosmoDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy. katiadicosmo@yahoo.it.
G De MarcoDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
P AgrettiLaboratory of Chemistry and Endocrinology, University Hospital of Pisa, Pisa, Italy.
E FerrariniDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
A DimidaDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
P FalcettaDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
S BenvengaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
P VittiDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
M TonaccheraDepartment of Clinical and Experimental Medicine, Endocrinology Unit, University of Pisa, via Paradisa 2, 56124, Pisa, Italy.
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMonocarboxylate transporter 8 (MCT8) is the first thyroid hormone transporter that has been linked to a human disease. Besides genetic alterations other factors might impair MCT8 activity.

aimThis study aimed at investigating whether some common drugs having a structural similarity with TH and/or whose treatment is associated with thyroid function test abnormalities, or which behave as antagonists of TH action can inhibit MCT8-mediated T

methods[

resultsDexamethasone significantly inhibited T

conclusionThis study shows a novel effect of some common drugs, which is inhibition of T

Indexed as

Analysis of VarianceAnti-Anxiety AgentsAnti-Arrhythmia AgentsDexamethasoneDietary SupplementsDrug Evaluation, PreclinicalGlucocorticoidsHumansMonocarboxylic Acid TransportersSymportersTriiodothyronineAnti-Anxiety AgentsAnti-Arrhythmia AgentsDexamethasoneGlucocorticoidsMonocarboxylic Acid TransportersSLC16A2 protein, humanSymportersTriiodothyronineDexamethasoneMCT8MCT8 inhibitorsT3 uptake

Identifiers

PMID34850364
OpenAlexW3216897406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.