ArticleImmunogenetics2022
Recurrent expansions of B30.2-associated immune receptor families in fish.
Article in Immunogenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Disruption of Myd88 in a salmonid epithelioid cell line reveals its contribution to bacterial detection and immune response.Cell and tissue research · 2025Article
- Nearly T2T, phased genome assemblies of corals reveal haplotype diversity and the evolutionary process of gene expansion.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi.PLoS genetics · 2025Article
- Tripartite motif 2b (Journal of virology · 2024Article
- Copy number variation and population-specific immune genes in the model vertebrate zebrafish.eLife · 2024Article
- Copy number variation and elevated genetic diversity at immune trait loci in Atlantic and Pacific herring.BMC genomics · 2024Article
- Genomic and transcriptome insight into the structure and immunity role of TRIM proteins in Chinese soft-shelled turtles (Pelodiscus sinensis) after Aeromonas hydrophila infection.Molecular biology reports · 2024Article
- Evolution and expression of the duck TRIM gene repertoire.Frontiers in immunology · 2023Article
- The evolution of innate immune receptors: investigating the diversity, distribution, and phylogeny of immune recognition across eukaryotes.Immunogenetics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B30.2 domains, also known as PRY/SPRY, are key components of specific subsets of two large families of proteins involved in innate immunity: the tripartite motif proteins (TRIMs) and the Nod-like receptors (NLRs). TRIM proteins are important, often inducible factors of antiviral innate immunity, targeting multiple steps of viral cycles through a variety of mechanisms. NLRs prime and regulate systemic innate defenses, especially against bacteria, and control inflammation. Large TRIM and NLR subsets characterized by the presence of a B30.2 domain have been reported from a few fish species including zebrafish and seem to be strongly prone to gene duplication/expansion. Here, we performed a large-scale survey of these receptors across about 150 fish genomes, focusing on ray-finned fishes. We assessed the number and genomic distribution of domains and domain combinations associated with TRIMs, NLRs, and other genes containing B30.2 domains and looked for gene expansion patterns across fish groups. We then used a model to test the impact of taxonomy, genome size, and environmental variables on the copy numbers of these genes. Our findings reveal novel domain structures, clade-specific gains and losses. They also assist with the timing of the gene expansions, reveal patterns associated with the MHC, and lay the groundwork for further studies delving deeper into the forces that drive the copy number variation of immune genes on a species level.
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