ArticlePlant physiology2022
The MADS-domain factor AGAMOUS-Like18 promotes somatic embryogenesis.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- AGL15 Promotion of Somatic Embryogenesis: Role and Molecular Mechanism.Frontiers in plant science · 2022Pooled it
- Genome-wide regulatory and interaction landscape underlying the functional divergence of rice AGAMOUS-like transcription factors.Journal of experimental botany · 2026Article
- TaGα knockout in wheat causes early heading and short organ length, with dose-dependent effects through various pathways.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The jujube pan-TE map identifies transposable element insertions associated with domestication and pericarp development.Horticulture research · 2026Article
- Advances in the use of morphogenic regulators and peptide regenerating factors for boosting plant transformation and genome editing.Frontiers in plant science · 2026Review
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
- MONOPTEROS isoform MP11ir plays a role during somatic embryogenesis in Arabidopsis thaliana.Plant physiology · 2025Article
- Identification of Auxin, Cytokinin, Transcription Factors, and Other Zygotic Embryogenesis-Related Genes inPlants (Basel, Switzerland) · 2025Article
- Insights into genetics of floral development in Amborella trichopoda Baill. through genome-wide survey and expression analysis of MADS-Box transcription factors.Scientific reports · 2025Article
- The MADS-Box Transcription Factor EjAGL18 Negatively Regulates Malic Acid Content in Loquat by RepressingInternational journal of molecular sciences · 2025Article
- Characterization analyses ofFrontiers in plant science · 2025Article
- Functional Analysis of the PoSERK-Interacting Protein PorbcL in the Embryogenic Callus Formation of Tree Peony (Plants (Basel, Switzerland) · 2024Article
- Epigenetic modifications and miRNAs determine the transition of somatic cells into somatic embryos.Plant cell reports · 2023Review
- Regulatory mechanisms of the LBD40 transcription factor inPlant direct · 2023Article
- Nuclear Localization of G3BP6 Is Essential for the Flowering Transition inBiomolecules · 2023Article
- Transcriptome Landscape Analyses of the Regulatory Network for Zygotic Embryo Development inInternational journal of molecular sciences · 2023Article
- Multifaceted roles of transcription factors during plant embryogenesis.Frontiers in plant science · 2023Review
- Revisiting AGAMOUS-LIKE15, a Key Somatic Embryogenesis Regulator, Using Next Generation Sequencing Analysis inInternational journal of molecular sciences · 2022Article
- New insights in transcriptional control of somatic embryogenesis: the role of AGAMOUS-like 18.Plant physiology · 2022Article
- Molecular Determinants ofFrontiers in plant science · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AGAMOUS-Like 18 (AGL18) is a MADS domain transcription factor (TF) that is structurally related to AGL15. Here we show that, like AGL15, AGL18 can promote somatic embryogenesis (SE) when ectopically expressed in Arabidopsis (Arabidopsis thaliana). Based on loss-of-function mutants, AGL15 and AGL18 have redundant functions in developmental processes such as SE. To understand the nature of this redundancy, we undertook a number of studies to look at the interaction between these factors. We studied the genome-wide direct targets of AGL18 to characterize its roles at the molecular level using chromatin immunoprecipitation (ChIP)-SEQ combined with RNA-SEQ. The results demonstrated that AGL18 binds to thousands of sites in the genome. Comparison of ChIP-SEQ data for AGL15 and AGL18 revealed substantial numbers of genes bound by both AGL15 and AGL18, but there were also differences. Gene ontology analysis revealed that target genes were enriched for seed, embryo, and reproductive development as well as hormone and stress responses. The results also demonstrated that AGL15 and AGL18 interact in a complex regulatory loop, where AGL15 inhibited transcript accumulation of AGL18, while AGL18 increased AGL15 transcript accumulation. Co-immunoprecipitation revealed an interaction between AGL18 and AGL15 in somatic embryo tissue. The binding and expression analyses revealed a complex crosstalk and interactions among embryo TFs and their target genes. In addition, our study also revealed that phosphorylation of AGL18 and AGL15 was crucial for the promotion of SE.
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