ArticleNeuro-oncology2022
Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study.
Article in Neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- Multidisciplinary recommendations for routine follow-up of isocitrate dehydrogenase‑mutant glioma in 2026: Adapting clinical practice to the molecular era.Neuro-oncology practice · 2026Review
- Addressing connectomic constraints in early practice of awake-guided neurosurgery: a four-year prospective case-matched analysis.Acta neurochirurgica · 2026Article
- Multimodal techniques for maximal safe resection of IDH-mutant low-grade glioma involving corpus callosum, a retrospective study and prognosis analysis.Chinese neurosurgical journal · 2026Article
- Reliable cognitive changes the first year following guideline-based treatment of isocitrate dehydrogenase mutated gliomas: A longitudinal multicenter study.Neuro-oncology · 2026Article
- Neuropsychological outcomes following awake surgery in adult glioma patients: A systematic review.Neuro-oncology practice · 2026Article
- The neuropsychological outcome of patients undergoing intraoperative MRI surgery for insular infiltrating gliomas.Journal of neuro-oncology · 2026Article
- The future of neurosurgical oncology lies in cognitive neurosciences: understanding brain processing is much more valuable than surgical technology.Frontiers in oncology · 2026Article
- Eloquent glioma resection assisted by brain connectomics: A new tool for awake neurosurgery.Surgical neurology international · 2026Article
- Neurocognitive outcomes following glioma diagnosis and treatment: A systematic review.Brain & spine · 2026Review
- Asleep motor mapping in resected low-grade gliomas -a population based multicenter study.Brain & spine · 2026Article
- Perioperative neuropsychological assessment reveals dynamic changes in neurocognitive function following brain tumor surgery.Brain & spine · 2026Article
- Connectomics in brain tumor surgery: large-scale clinical feasibility and hypothesis-generating tractometry findings.Journal of neuro-oncology · 2025Article
- Bibliometric evaluation of research trends and hotspots concerning the interaction between immune checkpoint inhibitors and glioma.Discover oncology · 2025Article
- Awake surgery with direct electrical stimulation mapping and real-time cognitive monitoring for functionally guided tumor resection: how we do it.Acta neurochirurgica · 2025Article
- Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study.Journal of neuro-oncology · 2025Article
- Health-related quality of life in 62 patients with diffuse low-grade glioma during a non-therapeutic and progression-free phase: a cross-sectional study.Journal of neuro-oncology · 2025Article
- Long-term autonomy, professional activities, cognition, and overall survival after awake functional-based surgery in patients with IDH-mutant grade 2 gliomas: a retrospective cohort study.The Lancet regional health. Europe · 2024Article
- Functional and oncological outcomes following more than three consecutive surgical resections for multiple relapses of initially grade 2 IDH-mutated gliomas.Acta neurochirurgica · 2024Article
- Perioperative Neurocognitive Function in Glioma Surgery.Current oncology reports · 2024Review
- Verbal fluency predicts work resumption after awake surgery in low-grade glioma patients.Acta neurochirurgica · 2024Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAwake surgery with intraoperative electrical mapping emerged as a gold-standard approach in newly diagnosed diffuse low-grade glioma (DLGG) to optimize the extent of resection (EOR) while sparing critical brain structures. However, no study has assessed to what extent cognitive recovery occurs following awake mapping-guided neurosurgery in a large, longitudinal, and homogeneous series of DLGG.
methodsA longitudinal study on the cognitive status of 157 DLGG patients was performed. Neuropsychological assessments were done before and three months after awake mapping-based surgery. Z-scores and variations of Z-scores were computed to determine the number of patients with cognitive deficit(s) or decline. Clinical, surgical, and histopathological variables were studied to investigate factors contributing to neurocognitive outcomes.
resultsEighty-seven patients (55.4%) had preoperative cognitive impairments. Statistical analysis between the preoperative (baseline) and postoperative assessments demonstrated a significant difference in three domains (Executive, Psychomotor Speed and Attention, Verbal Episodic Memory). Eighty-six percent of patients exhibited no postoperative cognitive decline, and among them, 10% exhibited cognitive improvement. The mean EOR was 92.3%±7.8%. The EOR, postoperative volume, and tumor lateralization had a significant association with cognitive decline. No patients demonstrated permanent postoperative neurologic deficits, but 5.8% did not resume their preoperative professional activities. The 5-year survival rate was 82.2%.
conclusionsThis is the largest series ever reported with systematic longitudinal neuropsychological assessment. 86% of patients demonstrated no cognitive decline despite large resections and only 5.8% did not return to work. This work supports the practice of awake surgery with cognitive mapping as safe and effective in DLGG patients.
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