ArticleNucleic acids research2022
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.
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Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
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94citing papers in PubMed, 1 pooled it
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94 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Protein Sequence Analysis landscape: A Systematic Review of Task Types, Databases, Datasets, Word Embeddings Methods, and Language Models.Database : the journal of biological databases and curation · 2025Pooled it
- Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins.Nature communications · 2026Article
- Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila.Nucleic acids research · 2026Article
- Navigating condensate micropolarity to enhance small-molecule drug targeting.Nature chemical biology · 2026Article
- ESMDisPred: A Structure-Aware CNN-Transformer Architecture for Intrinsically Disordered Protein Prediction.bioRxiv : the preprint server for biology · 2026Article
- ProteoformDB: an integrative database for functional roles of proteoforms.Database : the journal of biological databases and curation · 2026Article
- Expose flexible conformations for intrinsically disordered protein.Current research in structural biology · 2025Article
- MarkerPredict: predicting clinically relevant predictive biomarkers with machine learning.NPJ systems biology and applications · 2025Article
- Neurodegeneration Through the Lens of Bioinformatics Approaches: Computational Mechanisms of Protein Misfolding.International journal of molecular sciences · 2025Review
- Programming cellular condensates for living materials using an intrinsically disordered protein display platform.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeting protein disorder: the next hurdle in drug discovery.Nature reviews. Drug discovery · 2025Review
- Article
- Hydrophobicity in Intrinsically Disordered Protein Force Fields: Implications for Conformational Ensembles and Protein-Protein Interactions.The journal of physical chemistry. B · 2025Article
- Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin.Nucleic acids research · 2025Article
- Genome-Wide Characterization of Wholly Disordered Proteins inInternational journal of molecular sciences · 2025Article
- MEDOC: A Fast, Scalable, and Mathematically Exact Algorithm for the Site-Specific Prediction of the Protonation Degree in Large Disordered Proteins.Journal of chemical information and modeling · 2025Article
- Prediction of Disordered Linkers Using APOD.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Prediction of Intrinsic Disorder Functions with DEPICTER2.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Accurate and Fast Prediction of Intrinsic Disorder Using flDPnn.Methods in molecular biology (Clifton, N.J.) · 2025Article
- LCRAnnotationsDB: a database of low complexity regions functional and structural annotations.BMC genomics · 2024Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
61 authors.
Federica QuagliaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy.ORCID 0000-0002-0341-4888
Bálint MészárosStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.ORCID 0000-0003-0919-4449
Edoardo SalladiniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0002-5152-5953
András HatosDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0001-9224-9820
Rita PancsaInstitute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.ORCID 0000-0003-0849-9312
Lucía B ChemesInstituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina.ORCID 0000-0003-0192-9906
Mátyás PajkosDepartment of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary.ORCID 0000-0001-5791-9825
Tamas LazarVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium.ORCID 0000-0001-7496-6711
Samuel Peña-DíazInstitut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-2902-823X
Jaime SantosInstitut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0001-9045-7765
Veronika ÁcsInstitute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.ORCID 0000-0001-6260-7287
Nazanin FarahiVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium.ORCID 0000-0002-6834-8578
Erzsébet FichóInstitute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.ORCID 0000-0002-3965-8438
Maria Cristina AspromonteDepartment of Woman and Child Health, University of Padova, Padova, Italy.ORCID 0000-0002-4937-6952
Claudio BassotScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.ORCID 0000-0001-7161-9028
Anastasia ChasapiBiological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece.ORCID 0000-0003-1986-5007
Norman E DaveyInstitute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London, UK.ORCID 0000-0001-6988-4850
Radoslav DavidovićLaboratory for Bioinformatics and Computational Chemistry, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia.ORCID 0000-0002-6097-6203
Laszlo DobsonStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.ORCID 0000-0003-2765-3872
Arne ElofssonScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.ORCID 0000-0002-7115-9751
Gábor ErdősDepartment of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary.ORCID 0000-0001-6218-5192
Pascale GaudetSwiss-Prot group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland.ORCID 0000-0003-1813-6857
Michelle GiglioInstitute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0001-7628-5565
Juliana GlavinaInstituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina.ORCID 0000-0001-6336-1290
Javier IserteBioinformatics Unit, Fundación Instituto Leloir, Buenos Aires, C1405BWE, Argentina.ORCID 0000-0003-0056-1177
Valentín IglesiasInstitut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-6133-0869
Zsófia KálmánFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, 1083 Budapest, Hungary.ORCID 0000-0003-4634-0433
Matteo LambrughiCancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark.ORCID 0000-0002-0894-8627
Emanuela LeonardiDepartment of Woman and Child Health, University of Padova, Padova, Italy.ORCID 0000-0001-8486-8461
Sonia LonghiLab. Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France.ORCID 0000-0002-6829-6771
Sandra Macedo-RibeiroInstituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-7698-1170
Emiliano MaianiCancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark.ORCID 0000-0003-1432-5394
Julia MarchettiDepartamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.ORCID 0000-0002-2886-3647
Cristina Marino-BusljeBioinformatics Unit, Fundación Instituto Leloir, Buenos Aires, C1405BWE, Argentina.ORCID 0000-0002-6564-1920
Attila MészárosVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium.ORCID 0000-0002-4578-4879
Alexander Miguel MonzonDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0003-0362-8218
Giovanni MinerviniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0001-7013-5785
Suvarna NadendlaInstitute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0003-3643-281X
Juliet F NilssonLab. Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France.ORCID 0000-0003-4203-5263
Marian NovotnýDep. of Cell Biology, Faculty of Science, Vinicna 7, 128 43, Prague, Czech Republic.ORCID 0000-0001-8788-3202
Christos A OuzounisBiological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece.ORCID 0000-0002-0086-8657
Nicolás PalopoliDepartamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.ORCID 0000-0001-7925-6436
Elena PapaleoCancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark.ORCID 0000-0002-7376-5894
Pedro José Barbosa PereiraInstituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal.ORCID 0000-0003-0969-5438
Gabriele PozzatiScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.ORCID 0000-0002-4303-9939
Vasilis J PromponasBioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.ORCID 0000-0003-3352-4831
Jordi PujolsInstitut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0001-9424-5866
Alma Carolina Sanchez RochaDepartment of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague , Czech Republic.ORCID 0000-0001-7395-9173
Martin SalasDepartamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.ORCID 0000-0001-6352-1282
Luciana Rodriguez SawickiDepartamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.ORCID 0000-0001-5782-6573
Eva SchadInstitute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.ORCID 0000-0002-3006-2910
Aditi ShenoyScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden.ORCID 0000-0001-7748-2501
Tamás SzaniszlóDepartment of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary.ORCID 0000-0002-3130-9284
Konstantinos D TsirigosEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-5280-1107
Nevena VeljkovicLaboratory for Bioinformatics and Computational Chemistry, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia.ORCID 0000-0001-6562-5800
Gustavo ParisiDepartamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina.ORCID 0000-0001-7444-1624
Salvador VenturaInstitut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-9652-6351
Zsuzsanna DosztányiDepartment of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary.ORCID 0000-0002-3624-5937
Peter TompaInstitute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.ORCID 0000-0001-8042-9939
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0003-4525-7793
Damiano PiovesanDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0001-8210-2390
Funding
Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7MGene Ontology Consortium and KnowledgebaseU24HG012212 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTOPHER J MUNGALL, PAUL Warren STERNBERG · 2022 to 2026
$11.6MCancer Research UK 28159Cancer Research UK C68484/A28159NHGRI NIH HHS U24 HG012212NHGRI NIH HHS U41 HG002273
Abstract
The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
Indexed as
Databases, ProteinMolecular Sequence AnnotationSoftwareAmino Acid SequenceDatasets as TopicDNAGene OntologyHumansInternetIntrinsically Disordered ProteinsProtein BindingRNADNAIntrinsically Disordered ProteinsRNA
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