Evidence map›Paper›PMID 34850116›Full record

ArticleNucleic acids research2022

PLSDB: advancing a comprehensive database of bacterial plasmids.

Georges P Schmartz, Anna Hartung, Pascal Hirsch, Fabian Kern, Tobias Fehlmann, Rolf Müller, Andreas Keller

Abstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed.

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  11. Plasmid-encoded host reprogramming promotes plasmid dissemination.bioRxiv : the preprint server for biology · 2026
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  13. Novel transposon TnMicrobial genomics · 2026
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  20. V- and VNature communications · 2026
    Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georges P SchmartzChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-9627-9223
Anna HartungChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.
Pascal HirschChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.
Fabian KernChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-8223-3750
Tobias FehlmannChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-1967-2918
Rolf MüllerDepartment of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8 1, 66123 Saarbrücken, Germany.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-5361-0895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmids are known to contain genes encoding for virulence factors and antibiotic resistance mechanisms. Their relevance in metagenomic data processing is steadily growing. However, with the increasing popularity and scale of metagenomics experiments, the number of reported plasmids is rapidly growing as well, amassing a considerable number of false positives due to undetected misassembles. Here, our previously published database PLSDB provides a reliable resource for researchers to quickly compare their sequences against selected and annotated previous findings. Within two years, the size of this resource has more than doubled from the initial 13,789 to now 34,513 entries over the course of eight regular data updates. For this update, we aggregated community feedback for major changes to the database featuring new analysis functionality as well as performance, quality, and accessibility improvements. New filtering steps, annotations, and preprocessing of existing records improve the quality of the provided data. Additionally, new features implemented in the web-server ease user interaction and allow for a deeper understanding of custom uploaded sequences, by visualizing similarity information. Lastly, an application programming interface was implemented along with a python library, to allow remote database queries in automated workflows. The latest release of PLSDB is freely accessible under https://www.ccb.uni-saarland.de/plsdb.

Indexed as

Databases, GeneticUser-Computer InterfaceActinobacteriaBacillotaBacteriaBacteroidetesDrug Resistance, MicrobialInternetMetagenomicsMolecular Sequence AnnotationPlasmidsProteobacteriaSpirochaetalesTenericutesVirulence

Identifiers

PMID34850116
PMCPMC8728149

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.