Evidence map›Paper›PMID 34849925›Full record

ArticleInflammatory bowel diseases2022

Association Between Inflammatory Bowel Disease and Dementia: A Longitudinal Cohort Study.

Yuhao Sun, Jiawei Geng, Xuejie Chen, Hui Chen, Xiaoyan Wang, Jie Chen, Xue Li, Therese Hesketh

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory bowel diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yuhao SunCenter for Global Health, Zhejiang University, Hangzhou, China.
Jiawei GengCenter for Global Health, Zhejiang University, Hangzhou, China.
Xuejie ChenDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Hui ChenSchool of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Xiaoyan WangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Jie ChenCenter for Global Health, Zhejiang University, Hangzhou, China.ORCID 0000-0002-4029-4192
Xue LiSchool of Public Health and the Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Therese HeskethCenter for Global Health, Zhejiang University, Hangzhou, China.
Central South University · CNZhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CNUniversity College London · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundThe association between inflammatory bowel disease (IBD) and dementia remains uncertain. We aim to investigate whether IBD is associated with higher dementia risk.

methodsUsing multivariable Cox regression models, we analyzed the onset of all-cause dementia among 497,775 participants, including 5778 IBD patients in the UK Biobank as primary analysis. In secondary analysis, we further examined the difference in brain structure and cognitive function changes between IBD and non-IBD individuals. The diagnosis of IBD and dementia was confirmed with combination of primary care data, hospital inpatient data, death registry, and self-report data. Brain structure was measured by brain MRI as anatomic and tissue-specific volumes; cognitive function was tested in terms of reaction, visual episodic memory, verbal-numerical reasoning, and prospective memory.

resultsDuring a mean follow-up of 11.58 years, 100 and 6709 incident all-cause dementia with or without IBD were documented, respectively. In multivariable Cox regression model, hazard ratio for incident dementia among IBD patients was 1.14 (95% confidence interval [CI], 0.94-1.39; P=.182) comparing with non-IBD participants; no statistically significant difference was observed in their brain MRI measures of anatomic and tissue-specific volumes, whereas IBD patients had a significantly increased reaction time (β=12.32; 95% CI, 1.97, 22.67; P = .020). Results of subgroup and sensitivity analyses were consistent with the main analysis.

conclusionsOur study does not support a significant association between IBD and dementia. Further studies with better design and longer follow-up are needed to elucidate the association.

Indexed as

DementiaInflammatory Bowel DiseasesCohort StudiesHumansLongitudinal StudiesProportional Hazards ModelsRisk Factorsdementiainflammatory bowel diseaselongitudinal cohort

Identifiers

PMID34849925
PMCPMC9527613
OpenAlexW3214850851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.