Evidence map›Paper›PMID 34849824›Full record

ArticleG3 (Bethesda, Md.)2021

Genomic diversity, chromosomal rearrangements, and interspecies hybridization in the Ogataea polymorpha species complex.

Sara J Hanson, Eoin Ó Cinnéide, Letal I Salzberg, Kenneth H Wolfe, Jamie McGowan, David A Fitzpatrick, Kate Matlin

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara J HansonDepartment of Molecular Biology, Colorado College, Colorado Springs, CO 80903, USA.ORCID 0000-0001-7843-2565
Eoin Ó CinnéideSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin 4, Ireland.
Letal I SalzbergSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin 4, Ireland.
Kenneth H WolfeSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin 4, Ireland.ORCID 0000-0003-4992-4979
Jamie McGowanGenome Evolution Laboratory, Department of Biology, Maynooth University, Maynooth, Ireland.ORCID 0000-0002-4240-5175
David A FitzpatrickGenome Evolution Laboratory, Department of Biology, Maynooth University, Maynooth, Ireland.ORCID 0000-0001-7345-6998
Kate MatlinDepartment of Molecular Biology, Colorado College, Colorado Springs, CO 80903, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The methylotrophic yeast Ogataea polymorpha has long been a useful system for recombinant protein production, as well as a model system for methanol metabolism, peroxisome biogenesis, thermotolerance, and nitrate assimilation. It has more recently become an important model for the evolution of mating-type switching. Here, we present a population genomics analysis of 47 isolates within the O. polymorpha species complex, including representatives of the species O. polymorpha, Ogataea parapolymorpha, Ogataea haglerorum, and Ogataea angusta. We found low levels of nucleotide sequence diversity within the O. polymorpha species complex and identified chromosomal rearrangements both within and between species. In addition, we found that one isolate is an interspecies hybrid between O. polymorpha and O. parapolymorpha and present evidence for loss of heterozygosity following hybridization.

Indexed as

SaccharomycetalesGenomicsPeroxisomeschromosomal rearrangementsinterspecies hybridizationmating-type switchingOgataeapopulation genomics

Identifiers

PMID34849824
PMCPMC8496258

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.