ArticleEuropean heart journal2022
Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study.BMC cardiovascular disorders · 2026Article
- Feasibility of Zero-Dimensional-Model-Based Pulse Waveform Analysis as a Tool to Detect Ascending Thoracic Aortic Aneurysm Growth.Journal of biomechanical engineering · 2026Article
- Integrative cross-tissue transcriptome-wide association and metabolomic analysis reveals novel genetic risk loci for aortic aneurysm.Frontiers in nutrition · 2026Article
- Article
- Global, regional, and national burden of aortic aneurysm disease and its attributable risk factor, 1990-2021: a systematic analysis for the global burden of disease study 2021.Internal and emergency medicine · 2025Article
- Thoracic aortic aneurysm.Nature reviews. Disease primers · 2025Review
- Sex-related differences in the clinical course of aortic root and ascending aortic aneurysms: the DisSEXion Study.European heart journal · 2025Article
- Estimating nonlinear anisotropic properties of healthy and aneurysm ascending aortas using magnetic resonance imaging.Biomechanics and modeling in mechanobiology · 2025Article
- Association of cardiovascular disease and urate levels with aortic aneurysm: a bilateral mendelian randomization study.Scientific reports · 2024Article
- Review
- Longitudinal health-related quality of life in people with thoracic aortic aneurysms.The British journal of surgery · 2024Observational
- Inequalities for women diagnosed with distal arch and descending thoracic aortic aneurysms: results from the Effective Treatments for Thoracic Aortic Aneurysms (ETTAA) cohort study.The British journal of surgery · 2024Observational
- Assessing the role of an artificial intelligence assessment tool for thoracic aorta diameter on routine chest CT.The British journal of radiology · 2023Article
- The Long-Term Outcome and Quality of Life after Replacement of the Ascending Aorta.Journal of clinical medicine · 2023Article
- A Rare Case of Sudden Death due to Rupture of Saccular Descending Thoracic Aortic Aneurysm with Dissection.Heart views : the official journal of the Gulf Heart AssociationArticle
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12 authors at 9 institutions in 1 country.
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Abstract
aimsTo observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. METHODS AND
resultsProspective study of UK National Health Service (NHS) patients aged ≥18 years, with new/existing arch or descending thoracic aortic aneurysms of ≥4 cm diameter, followed up until death, intervention, withdrawal, or July 2019. Outcomes were aneurysm growth, survival, quality of life (using the EQ-5D-5L utility index), and hospital admissions. Between 2014 and 2018, 886 patients were recruited from 30 NHS vascular/cardiothoracic units. Maximum aneurysm diameter was in the descending aorta in 725 (82%) patients, growing at 0.2 cm (0.17-0.24) per year. Aneurysms of ≥4 cm in the arch increased by 0.07 cm (0.02-0.12) per year. Baseline diameter was related to age and comorbidities, and no clinical correlates of growth were found. During follow-up, 129 patients died, 64 from aneurysm-related events. Adjusting for age, sex, and New York Heart Association dyspnoea index, risk of death increased with aneurysm size at baseline [hazard ratio (HR): 1.88 (95% confidence interval: 1.64-2.16) per cm, P < 0.001] and with growth [HR: 2.02 (1.70-2.41) per cm, P < 0.001]. Hospital admissions increased with aneurysm size [relative risk: 1.21 (1.05-1.38) per cm, P = 0.008]. Quality of life decreased annually for each 10-year increase in age [-0.013 (-0.019 to -0.007), P < 0.001] and for current smoking [-0.043 (-0.064 to -0.023), P = 0.004]. Aneurysm size was not associated with change in quality of life.
conclusionInternational guidelines should consider increasing monitoring intervals to 12 months for small aneurysms and increasing intervention thresholds. Individualized decisions about surveillance/intervention should consider age, sex, size, growth, patient characteristics, and surgical risk.
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