ArticleCerebral cortex (New York, N.Y. : 1991)2022
Higher order visual areas enhance stimulus responsiveness in mouse primary visual cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A shared multi-feature population code for sensory reliability across mouse visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex.Nature communications · 2026Article
- Circuit-level dynamics and propagation of slow wave activity modulate their interplay during the awakening process.iScience · 2025Article
- Article
- Cell-type-specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states.PLoS computational biology · 2025Article
- Testing the role of spontaneous activity in visuospatial perception with patterned optogenetics.PloS one · 2025Article
- The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report.eNeuro · 2024Article
- How 'visual' is the visual cortex? The interactions between the visual cortex and other sensory, motivational and motor systems as enabling factors for visual perception.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Functional (ir)Relevance of Posterior Parietal Cortex during Audiovisual Change Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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Authors and funding
4 authors.
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Abstract
Over the past few years, the various areas that surround the primary visual cortex (V1) in the mouse have been associated with many functions, ranging from higher order visual processing to decision-making. Recently, some studies have shown that higher order visual areas influence the activity of the primary visual cortex, refining its processing capabilities. Here, we studied how in vivo optogenetic inactivation of two higher order visual areas with different functional properties affects responses evoked by moving bars in the primary visual cortex. In contrast with the prevailing view, our results demonstrate that distinct higher order visual areas similarly modulate early visual processing. In particular, these areas enhance stimulus responsiveness in the primary visual cortex, by more strongly amplifying weaker compared with stronger sensory-evoked responses (for instance specifically amplifying responses to stimuli not moving along the direction preferred by individual neurons) and by facilitating responses to stimuli entering the receptive field of single neurons. Such enhancement, however, comes at the expense of orientation and direction selectivity, which increased when the selected higher order visual areas were inactivated. Thus, feedback from higher order visual areas selectively amplifies weak sensory-evoked V1 responses, which may enable more robust processing of visual stimuli.
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