Evidence map›Paper›PMID 34849631›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Lack of Convincing Evidence That Borrelia burgdorferi Infection Causes Either Alzheimer Disease or Lewy Body Dementia.

Gary P Wormser, Adriana Marques, Charles S Pavia, Ira Schwartz, Henry M Feder, Andrew R Pachner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Call for Caution to ConsiderPathogens (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Gary P WormserDepartment of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA.
Adriana MarquesLaboratory of Clinical Microbiology and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Charles S PaviaDepartment of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA.
Ira SchwartzDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.
Henry M FederUniversity of Connecticut Medical Center and Connecticut Children's Medical Center, Farmington and Hartford, Connecticut, USA.
Andrew R PachnerDepartment of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
New York Medical College · USDartmouth–Hitchcock Medical Center · USNational Institute of Allergy and Infectious Diseases · USNew York Institute of Technology · USUniversity of Connecticut · US

Funding

Assessment Of Patients With Borrelia InfectionZIAAI000695 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MARQUES, ADRIANA R · 2009 to 2025
$8.8M
6 · The paper itself

Abstract

The role that microorganisms might have in the development of Alzheimer disease is a topic of considerable interest. In this article, we discuss whether there is credible evidence that Lyme disease is a cause of Alzheimer disease and critically review a recent publication that claimed that Borrelia burgdorferi sensu stricto infection, the primary cause of Lyme disease in the United States, may cause Lewy body dementia. We conclude that no convincing evidence exists that Lyme disease is a cause of either Alzheimer disease or Lewy body dementia.

Indexed as

Alzheimer DiseaseBorrelia burgdorferiBorrelia burgdorferi GroupLewy Body DiseaseLyme DiseaseHumansUnited StatesAlzheimer diseaseBorrelia burgdorferidementiaLewy body dementiaLyme disease

Identifiers

PMID34849631
PMCPMC9410724
OpenAlexW3214794262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.