ArticleCerebral cortex (New York, N.Y. : 1991)2022
Striatal BOLD and Midfrontal Theta Power Express Motivation for Action.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06027723 (Effects of Acute Nicotine Administration on Motivational Mechanisms), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Acute Nicotine Administration on Motivational Mechanisms
Who cites it
11 citing papers in PubMed.
- Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in learning.PLoS biology · 2026Article
- Dopamine dynamics in human anterior cingulate cortex during Pavlovian-instrumental conflict.bioRxiv : the preprint server for biology · 2026Article
- Intertemporal Pavlovian biases and links with mental health in the general population.Cognitive, affective & behavioral neuroscience · 2025Article
- Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour.Cognitive, affective & behavioral neuroscience · 2025Article
- Improving the Reliability of the Pavlovian Go/No-Go Task for Computational Psychiatry Research.Computational psychiatry (Cambridge, Mass.) · 2025Article
- High stakes slow responding, but do not help overcome Pavlovian biases in humans.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases.Cognitive, affective & behavioral neuroscience · 2024Article
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- A thin line between conflict and reaction time effects on EEG and fMRI brain signals.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Transcranial direct-current stimulation enhances Pavlovian tendencies during intermittent loss of control.Frontiers in psychiatry · 2023Article
- Comparing Discounting of Potentially Real Rewards and Losses by Means of Functional Magnetic Resonance Imaging.Frontiers in systems neuroscience · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Action selection is biased by the valence of anticipated outcomes. To assess mechanisms by which these motivational biases are expressed and controlled, we measured simultaneous EEG-fMRI during a motivational Go/NoGo learning task (N = 36), leveraging the temporal resolution of EEG and subcortical access of fMRI. VmPFC BOLD encoded cue valence, importantly predicting trial-by-trial valence-driven response speed differences and EEG theta power around cue onset. In contrast, striatal BOLD encoded selection of active Go responses and correlated with theta power around response time. Within trials, theta power ramped in the fashion of an evidence accumulation signal for the value of making a "Go" response, capturing the faster responding to reward cues. Our findings reveal a dual nature of midfrontal theta power, with early components reflecting the vmPFC contribution to motivational biases, and late components reflecting their striatal translation into behavior, in line with influential recent "value of work" theories of striatal processing.
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