ArticleEClinicalMedicine2021
Brain structural associations with depression in a large early adolescent sample (the ABCD study®).
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.Molecular psychiatry · 2026Pooled it
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Anterior Cingulate Cortex Reactivity to Social Stimuli Marks Individual Differences to Peer Victimization on Internalizing Symptoms in Adolescence.JAACAP open · 2026Article
- Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.Translational psychiatry · 2026Article
- Longitudinal associations between depressive symptoms and brain structure across late childhood and adolescence: A panel network analysis study.medRxiv : the preprint server for health sciences · 2026Article
- Structural and functional atypicality in the temporal cortex are associated with auditory perception in maltreated children.Scientific reports · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children.Npj mental health research · 2025Article
- Genome-wide association study of adolescent-onset depression.medRxiv : the preprint server for health sciences · 2025Article
- Using deep learning to predict internalizing problems from brain structure in youth.Translational psychiatry · 2025Article
- Causal structural covariance network identifies progressive gray matter atrophy in adolescents with major depressive disorder.Psychological medicine · 2025Article
- Longitudinal Prediction of Adolescent Depression from Environmental and Polygenic Risk Scores.medRxiv : the preprint server for health sciences · 2025Article
- Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors.Neuroscience bulletin · 2025Article
- Assessing a prediction model for depression risk using an early adolescent sample with self-reported depression.JCPP advances · 2025Article
- Relationships between wellbeing polygenic scores, brain structure, and psychopathology in children.medRxiv : the preprint server for health sciences · 2025Article
- Using deep learning to predict internalizing problems from brain structure in youth.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression.Nature communications · 2025Article
- Resting-State Sensory-Motor Connectivity between Hand and Mouth as a Neural Marker of Socioeconomic Disadvantage, Psychosocial Stress, Cognitive Difficulties, Impulsivity, Depression, and Substance Use in Children.Journal of cellular neuroscience · 2025Article
- Mean Diffusivity of the Left Caudal Anterior Cingulate Cortex and Past Major Depressive Disorder in Adolescents: Evidence from the ABCD Study.Journal of cellular neuroscience · 2025Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is the leading cause of disability worldwide with > 50% of cases emerging before the age of 25 years. Large-scale neuroimaging studies in depression implicate robust structural brain differences in the disorder. However, most studies have been conducted in adults and therefore, the temporal origins of depression-related imaging features remain largely unknown. This has important implications for understanding aetiology and informing timings of potential intervention.
methodsHere, we examine associations between brain structure (cortical metrics and white matter microstructural integrity) and depression ratings (from caregiver and child), in a large sample (
findingsWe report significantly decreased global cortical and white matter metrics, and regionally in frontal, limbic and temporal areas in adolescent depression (Cohen's
interpretationDepression ratings in early adolescence were associated with similar imaging findings to those seen in adult depression samples, suggesting neuroanatomical abnormalities may be present early in the disease course, arguing for the importance of early intervention. Associations between socio-environmental factors and reporter discrepancy warrant further consideration, both in the wider context of the assessment of adolescent psychopathology, and in relation to their role in aetiology.
fundingWellcome Trust (References: 104036/Z/14/Z and 220857/Z/20/Z) and the Medical Research Council (MRC, Reference: MC_PC_17209).
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