ArticleEClinicalMedicine2021
Evaluating the Impact and Rationale of Race-Specific Estimations of Kidney Function: Estimations from U.S. NHANES, 2015-2018.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Bilateral Adrenal Primary Aldosteronism Is Uniformly Present in Hypertensive Afro-Caribbean First-Generation Immigrants to Western Canada.Journal of the American Heart Association · 2026Article
- Anti-Black racism in Canadian clinical tools: Ending race-based correction.Canadian family physician Medecin de famille canadien · 2026Article
- Evaluation of race-free eGFR equations in individuals of different ethnicity.Blood pressure · 2025Article
- CKD Prevalence and Incidence in Hispanic/Latino Adults Using Race-Free Estimated Glomerular Filtration Rate Equations.Kidney medicine · 2025Article
- Association of race and 30-day postoperative complications after urologic oncology surgery.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Article
- Estimation of age and sex-specific Glomerular Filtration Rate and its association with mortality and atherosclerotic cardiovascular outcomes in the Abu Dhabi population; A Retrospective Cohort Study.Journal of nephrology · 2025Article
- Gender disparities in the association between atherogenic index of plasma and chronic kidney disease.BMC public health · 2025Article
- Assessing the Current Limitations of Large Language Models in Advancing Health Care Education.JMIR formative research · 2025Article
- The association between bone density of lumbar spines and different daily protein intake in different renal function.Renal failure · 2024Article
- Bias in Prediction Models to Identify Patients With Colorectal Cancer at High Risk for Readmission After Resection.JCO clinical cancer informatics · 2024Article
- Reporting of Race, Ethnicity, and Ancestry Remains Inadequate in Kidney Research.Kidney international reports · 2024Article
- Race as a Risk Marker, Not a Risk Factor: Revising Race-Based Algorithms to Protect Racially Oppressed Patients.Journal of general internal medicine · 2024Article
- Considering Adverse Effects of Common Antihypertensive Medications in the ED.Current hypertension reports · 2024Review
- Race and ethnicity in physiological research: When socio-political constructs and biology collide.Experimental physiology · 2024Article
- Xenotransplantation could either be a friend or foe of healthcare equity.Communications medicine · 2024Article
- Predictors of chronic kidney disease survival in type 2 diabetes: a 12-year retrospective cohort study utilizing estimated glomerular filtration rate.Scientific reports · 2024Article
- Impact of race-based calculations of eGFR on the management of muscle invasive bladder cancer.American journal of clinical and experimental urology · 2024Article
- Reassessing the Use of Race in Clinical Algorithms: An Interactive, Case-Based Session for Medical Students Using eGFR.MedEdPORTAL : the journal of teaching and learning resources · 2024Article
- Association between dietary vitamin E intake and chronic kidney disease events in US adults: a cross-sectional study from NHANES 2009-2016.Clinical kidney journal · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundStandard equations for estimating glomerular filtration rate (eGFR) employ race multipliers, systematically inflating eGFR for Black patients. Such inflation is clinically significant because eGFR thresholds of 60, 30, and 20 ml/min/1.73m
methodsUsing population-representative cross-sectional data from the United States National Health and Nutrition Examination Survey (NHANES) from 2015-2018, eGFR values for Black Americans were calculated using the Modification of Diet in Renal Disease (MDRD) equation with and without the 1.21 race-specific coefficient using cohort data on age, sex, race, and serum creatinine.
findingsWithout the MDRD eGFR race adjustment, 3.3 million (10.4%) more Black Americans would reach a diagnostic threshold for Stage 3 Chronic Kidney Disease, 300,000 (0.7%) more would qualify for beneficial nephrologist referral, and 31,000 (0.1%) more would become eligible for transplant evaluation and waitlist inclusion.
interpretationThese findings suggest eGFR race coefficients may contribute to racial differences in the management of kidney. We provide recommendations for addressing this issue at institutional and individual levels.
fundingNo external funding was received for this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.