Evidence map›Paper›PMID 34849414›Full record

ArticlePhysics and imaging in radiation oncology2021

Intensity standardization methods in magnetic resonance imaging of head and neck cancer.

Kareem A Wahid, Renjie He, Brigid A McDonald, Brian M Anderson, Travis Salzillo, Sam Mulder, Jarey Wang, Christina Setareh Sharafi, Lance A McCoy, Mohamed A Naser and 9 more

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  7. An MRI-derived head-neck finite element model.Biomechanics and modeling in mechanobiology · 2025
    Article
  8. Quantitative cardiac magnetic resonance standardized signal intensity comparison in dilated cardiomyopathy vs. cardiac sarcoidosis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Improving the U-Net Configuration for Automated Delineation of Head and Neck Cancer on MRI.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025
    Article
  13. Baseline [European journal of nuclear medicine and molecular imaging · 2024
    Article
  14. Review
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  17. A transformer-based hierarchical registration framework for multimodality deformable image registration.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2023
    Article
  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kareem A WahidDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Renjie HeDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Brigid A McDonaldDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Brian M AndersonImaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Travis SalzilloDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sam MulderDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jarey WangDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Christina Setareh SharafiDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Lance A McCoyDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Mohamed A NaserDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sara AhmedDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Keith L SandersDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Abdallah S R MohamedDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Yao DingRadiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jihong WangRadiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Kate HutchesonHead and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Stephen Y LaiHead and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Clifton D FullerDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Lisanne V van DijkDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Funding

Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
Multiparametric Magnetic Resonance Imaging Artificial Intelligence Pipeline for Oropharyngeal Cancer Radiotherapy Treatment GuidanceF31DE031502 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WAHID, KAREEM · 2021 to 2023
$68k
NCATS NIH HHS TL1 TR003169NIDCR NIH HHS F31 DE031502NIDCR NIH HHS R01 DE028290
6 · The paper itself

Abstract

background and purposeConventional magnetic resonance imaging (MRI) poses challenges in quantitative analysis because voxel intensity values lack physical meaning. While intensity standardization methods exist, their effects on head and neck MRI have not been investigated. We developed a workflow based on healthy tissue region of interest (ROI) analysis to determine intensity consistency within a patient cohort. Through this workflow, we systematically evaluated intensity standardization methods for MRI of head and neck cancer (HNC) patients. MATERIALS AND

methodsTwo HNC cohorts (30 patients total) were retrospectively analyzed. One cohort was imaged with heterogenous acquisition parameters (HET cohort), whereas the other was imaged with homogenous acquisition parameters (HOM cohort). The standard deviation of cohort-level normalized mean intensity (SD NMI

resultsConsistency (SD NMI

conclusionsOur findings stress the importance of intensity standardization, either through the utilization of uniform acquisition parameters or specific intensity standardization methods, and the need for testing intensity consistency before performing quantitative analysis of HNC MRI.

Indexed as

HarmonizationHead and neck cancerMRINormalizationQuantitative analysisStandardization

Identifiers

PMID34849414
PMCPMC8607477

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.