Evidence map›Paper›PMID 34849393›Full record

ArticleInternational journal of cardiology. Heart & vasculature2021

The effect of azithromycin for management of HIV-associated chronic lung disease on right heart function: Results from the BREATHE trial.

Edith D Majonga, Gugulethu Newton Mapurisa, Andrea M Rehman, Grace McHugh, Tsitsi Bandason, Hilda Mujuru, Carmen Gonzalez-Martinez, Jon O Odland, Neil Kennedy, Rashida A Ferrand

Open access · goldAbstract read
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In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Edith D MajongaBiomedical Research & Training Institute, Harare, Zimbabwe.
Gugulethu Newton MapurisaDepartment of Paediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi.
Andrea M RehmanMRC International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Grace McHughBiomedical Research & Training Institute, Harare, Zimbabwe.
Tsitsi BandasonBiomedical Research & Training Institute, Harare, Zimbabwe.
Hilda MujuruDepartment of Paediatrics, University of Zimbabwe, Harare, Zimbabwe.
Carmen Gonzalez-MartinezMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Jon O OdlandFaculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway.
Neil KennedyDepartment of Paediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi.
Rashida A FerrandBiomedical Research & Training Institute, Harare, Zimbabwe.
Biomedical Research and Training Institute · ZWUniversity of Malawi · MWLondon School of Hygiene & Tropical Medicine · GBUniversity of Liverpool · GBUniversity of Pretoria · ZAUniversity of Zimbabwe · ZW

Funding

Medical Research Council MR/R010161/1Wellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

backgroundRight heart abnormalities and pulmonary hypertension (PH) may be secondary to chronic lung disease. Chronic lung disease is common in children with HIV. In the BREATHE trial (

methodsA standardised transthoracic echocardiogram using M-mode, two-dimensional and Doppler was performed, at baseline and at completion of weight-based AZM given weekly for 48 weeks. Linear regression was used to compare trial arms.

resultsA total of 169 participants (82 AZM arm; 87 placebo arm) were included. Participants in the placebo arm were older, median age 16.2 (13.0-18.2) vs 15.3 (12.9-17.4) years, p = 0.184 in the AZM arm. At baseline, right heart abnormalities (right ventricular systolic dysfunction (RVSD), dilatation, or PH) were observed in 7(4%). Following treatment, there was no difference in prevalence of RVSD between arms (p = 0.761). There was one incident case of suspected PH, and overall, no difference in pulmonary pressures.

conclusionIn children with HCLD, there was evidence of secondary cardiac effects, but AZM had no effect on right heart function. Long-term follow-up in children with HIV should be part of future research to understand the clinical implications of right heart abnormalities.

Indexed as

AdolescentsAfricaChildrenChronic lung diseaseHIVRight heart

Identifiers

PMID34849393
PMCPMC8609135
OpenAlexW3217487341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.