Evidence map›Paper›PMID 34849302›Full record

ReviewAmerican journal of stem cells2021

Reciprocal signals between nerve and epithelium: how do neurons talk with epithelial cells?

Sadaruddin Chachar, Jing Chen, Yumei Qin, Xia Wu, Haiyan Yu, Qiang Zhou, Xiaojiao Fan, Chaochen Wang, Isaac Brownell, Ying Xiao

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of stem cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sadaruddin ChacharCentral Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310020, Zhejiang, China.
Jing ChenDepartment of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University Hangzhou 310016, Zhejiang, China.
Yumei QinSchool of Food Science and Bioengineering, Zhejiang Gongshang University Hangzhou 310018, Zhejiang, China.
Xia WuDepartment of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310020, Zhejiang, China.
Haiyan YuDepartment of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310020, Zhejiang, China.
Qiang ZhouDepartment of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310020, Zhejiang, China.
Xiaojiao FanSchool of Pharmacy, Jiangsu University Zhenjiang, Jiangsu, China.
Chaochen WangDepartment of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University Hangzhou 310016, Zhejiang, China.
Isaac BrownellDermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda 20892, Maryland, USA.
Ying XiaoCentral Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310020, Zhejiang, China.
Sir Run Run Shaw Hospital · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most epithelium tissues continuously undergo self-renewal through proliferation and differentiation of epithelial stem cells (known as homeostasis), within a specialized stem cell niche. In highly innervated epithelium, peripheral nerves compose perineural niche and support stem cell homeostasis by releasing a variety of neurotransmitters, hormones, and growth factors and supplying trophic factors to the stem cells. Emerging evidence has shown that both sensory and motor nerves can regulate the fate of epithelial stem cells, thus influencing epithelium homeostasis. Understanding the mechanism of crosstalk between epithelial stem cells and neurons will reveal the important role of the perineural niche in physiological and pathological conditions. Herein, we review recent discoveries of the perineural niche in epithelium mainly in tissue homeostasis, with a limited touch in wound repair and pathogenesis.

Indexed as

crosstalkneurotransmitterPerineural nichestem celltissue maintenance

Identifiers

PMID34849302
PMCPMC8610808
OpenAlexW3215613225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.