ArticleJournal of clinical and translational science2021
Participation of rural patients in clinical trials at a multisite academic medical center.
Article in Journal of clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Race and trial region changes in cancer clinical trials between 2013 and 2024.Frontiers in medicine · 2026Pooled it
- Recruiting Rural Patients for Clinical Research: Lessons From a Colorectal Cancer Screening Trial.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026Trial
- Effective and cost-effective strategies for recruiting rural adults into a civic engagement and health behavior change research study.BMC public health · 2026Trial
- Remote Recruitment to Diversify Infant Research Participation: Lessons From the Infant Vaccine Biepository.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Trust-Centered Design and Feasibility Evaluation of an AI-Enabled Conversational Health Tool for Sexual and Reproductive Health Among Rural Young Adults: Protocol for a Mixed Methods Study.JMIR research protocols · 2026Article
- Meeting People Where They Are: Strategies for Improving Rural Representation in Clinical Research through Pragmatic Clinical Trials.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026Article
- Guiding principles for clinical research on substance use disorders in rural communities.Journal of substance use and addiction treatment · 2026Article
- Comparing Immediate Breast Reconstruction Rates in Rural and Urban Populations: A Global Systematic Review and Meta-Analysis: Comparer les taux de reconstruction mammaire immédiate dans les populations rurales et urbaines : une analyse systématique et méta-analyse globales.Plastic surgery (Oakville, Ont.) · 2026Review
- Differences in rural and urban patient perceptions of facilitative factors for cancer clinical trial participation.BMC health services research · 2025Article
- Public Perception of Clinical Trials and Its Predictors Among Polish Adults.Journal of clinical medicine · 2025Article
- 'The seagull theory: Where people fly in, gather information… fly out and nothing ever comes about': A qualitative exploration of barriers and enablers to research participation among adults with type 2 diabetes living in Australian rural communities.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Strategies for recruitment and retention of diverse and underserved cancer survivor and caregiver dyads in clinical trials.Contemporary clinical trials communications · 2025Article
- State of Geographic Access to Cancer Treatment Trials in the United States: Are Studies Located Where Patients Live?JCO oncology practice · 2025Article
- Duke Research at Pickett: The evolution of a free-standing research site partnering with communities toward health equity advancement.Journal of clinical and translational science · 2025Article
- Barriers to participation in clinical trials of rural older adult cancer survivors: A qualitative study.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Community engagement strategies improve recruitment and enrollment in a pragmatic clinical trial.Journal of clinical and translational science · 2025Article
- Improving Access to Patient-Focused, Decentralized Clinical Trials Requires Streamlined Regulatory Requirements: An ASCO Research Statement.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Geographic proximity to cardiovascular clinical trial sites: A National analysis in the United States.Current problems in cardiology · 2024Review
- Evaluating the Impact of Telemedicine on Diabetes Management in Rural Communities: A Systematic Review.Cureus · 2024Review
- Strengths and opportunities to clinical trial enrollment among BIPOC, rural dwelling patients in the northwest United States: a retrospective study.Frontiers in pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveClinical trials, which are mainly conducted in urban medical centers, may be less accessible to rural residents. Our aims were to assess participation and the factors associated with participation of rural residents in clinical trials.
methodsUsing geocoding, the residential address of participants enrolled into clinical trials at Mayo Clinic locations in Arizona, Florida, and the Midwest between January 1, 2016, and December 31, 2017, was categorized as urban or rural. The distance travelled by participants and trial characteristics was compared between urban and rural participants. Ordinal logistic regression analyses were used to evaluate whether study location and risks were associated with rural participation in trials.
resultsAmong 292 trials, including 136 (47%) cancer trials, there were 2313 participants. Of these, 731 (32%) were rural participants, which is greater than the rural population in these 9 states (19%,
conclusionsApproximately one in three clinical trial participants were rural residents versus one in five in the population. Rural residents travelled further to access clinical trials. The study-associated risks were not associated with the distribution of rural and urban participants in trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.