Evidence map›Paper›PMID 34849247›Full record

ArticleRoyal Society open science2021

Bayesian inference of a non-local proliferation model.

Zuzanna Szymańska, Jakub Skrzeczkowski, Błażej Miasojedow, Piotr Gwiazda

Abstract read
In one paragraph

Article in Royal Society open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zuzanna SzymańskaICM, University of Warsaw, ul. Tyniecka 15/17, 02-630 Warsaw, Poland.ORCID 0000-0002-2968-5627
Jakub SkrzeczkowskiFaculty of Mathematics, Informatics and Mechanics, University of Warsaw, ul. Banacha 2, 02-097 Warsaw, Poland.
Błażej MiasojedowFaculty of Mathematics, Informatics and Mechanics, University of Warsaw, ul. Banacha 2, 02-097 Warsaw, Poland.
Piotr GwiazdaInstitute of Mathematics, Polish Academy of Sciences, ul. Śniadeckich 8, 00-656 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From a systems biology perspective, the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental data. Having this in mind, in this paper, we aim at contributing to the improvement of many cancer models which contain a proliferation term. To this end, we propose a new non-local model of cell proliferation. We select data that are suitable to perform Bayesian inference for unknown parameters and we provide a discussion on the range of applicability of the model. Furthermore, we provide proof of the stability of posterior distributions in total variation norm which exploits the theory of spaces of measures equipped with the weighted flat norm. In a companion paper, we provide detailed proof of the well-posedness of the problem and we investigate the convergence of the escalator boxcar train (EBT) algorithm applied to solve the equation.

Indexed as

Bayesian inverse problemsnon-local cancer modelparameter estimationparticle methodproliferation functionstability of posterior distribution

Identifiers

PMID34849247
PMCPMC8611353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.