Evidence map›Paper›PMID 34849196›Full record

ArticleComputational and structural biotechnology journal2021

Gut microbiome signatures distinguish type 2 diabetes mellitus from non-alcoholic fatty liver disease.

Jiyeon Si, Giljae Lee, Hyun Ju You, Sae Kyung Joo, Dong Hyeon Lee, Bon Jeong Ku, Seoyeon Park, Won Kim, GwangPyo Ko

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  20. Effects ofMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jiyeon SiMedical Science Research Institute, School of Medicine, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
Giljae LeeDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Hyun Ju YouDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Sae Kyung JooDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Republic of Korea.
Dong Hyeon LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Republic of Korea.
Bon Jeong KuDepartment of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
Seoyeon ParkDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Won KimDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Republic of Korea.
GwangPyo KoDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Seoul National University · KRChungnam National University · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is closely associated with type 2 diabetes mellitus (T2D), and these two metabolic diseases demonstrate bidirectional influences. The identification of microbiome profiles that are specific to liver injury or impaired glucose metabolism may assist understanding of the role of the gut microbiota in the relationship between NAFLD and T2D. Here, we studied a biopsy-proven Asian NAFLD cohort (n = 329; 187 participants with NAFLD, 101 with NAFLD and T2D, and 41 with neither) and identified

Indexed as

ALT, alanine aminotransferaseBiomarkerBMI, body mass indexEnterotypeFBS, fasting blood sugarFDR, false discovery rateFLI, fatty liver indexGut microbiomeHbA1c, glycosylated hemoglobinLDL, low-density lipoproteinLPS, lipopolysaccharideMaAsLin2, microbiome multivariable association with linear models 2NAFLD, non-alcoholic fatty liver diseaseNAFL, non-alcoholic fatty liverNASH-CRN, non-alcoholic steatohepatitis clinical research networkNASH, non-alcoholic steatohepatitisNon-alcoholic fatty liver disease (NAFLD)PICRUSt2, phylogenetic investigation of communities by reconstruction of unobserved states 2T2D, type 2 diabetes mellitusType 2 diabetes mellitus

Identifiers

PMID34849196
PMCPMC8591343
OpenAlexW3208959745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.