Evidence map›Paper›PMID 34849100›Full record

ReviewActa ortopedica brasileira

HETEROTOPIC OSSIFICATION IN ACETABULAR FRACTURES: SYSTEMATIC REVIEW AND META-ANALYSIS OF PROPHYLAXIS.

Thiago Sanchez Pires Bueno, Gabriel Paris DE Godoy, Rebeca Barros Furukava, Nicole Takakura Gaggioli, Marcel Jun Sugawara Tamaoki, Fabio Teruo Matsunaga, João Carlos Belloti

Open access · goldAbstract readReview
In one paragraph

Review in Acta ortopedica brasileira. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Preventing complications during acetabular fracture surgery, a review.Journal of clinical orthopaedics and trauma · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thiago Sanchez Pires BuenoUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0001-9186-0062
Gabriel Paris DE GodoyUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0002-7874-7476
Rebeca Barros FurukavaUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0002-4033-5134
Nicole Takakura GaggioliUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0002-6103-5763
Marcel Jun Sugawara TamaokiUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0002-9539-4545
Fabio Teruo MatsunagaUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0001-7328-1446
João Carlos BellotiUniversidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.ORCID 0000-0003-3396-479X
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHeterotopic ossification is defined as the formation of trabecular bone in soft tissues. It is a common complication after surgical treatment of acetabular fractures. However, its prophylaxis and treatment are still controversial. The objective of this research is to evaluate the effectiveness of actions to prevent the development of heterotopic ossification after surgical correction of acetabular fractures.

methodsA systematic review was carried out with research in the databases PubMed/MEDLINE, Embase, LILACS and Cochrane until August 4, 2020, without restrictions on language and year of publication. Only randomized clinical studies carried out in humans without restrictions based on the dosage of treatments, use and duration of prophylaxis were included in this review.

resultsTwo studies compared the use of radiotherapy and indomethacin and three compared the use of indomethacin with a placebo or non-indomethacin group. The meta-analysis calculations did not indicate statistical differences between radiotherapy versus indomethacin (RR 1.45, IC 95% 0.97 to 2.17, p = 0,55) and indomethacin versus placebo or not indomethacin (RR 0.85, IC 95% 0.68 to 1.06, p = 0,59).

Indexed as

Bone FracturesClinical TrialDisease PreventionHeterotopicOssificationTherapeutics

Identifiers

PMID34849100
PMCPMC8601386
OpenAlexW3213709095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.