Observational studyInternational journal of obesity (2005)2022
Sensitization of the reinforcing value of high energy density foods is associated with increased zBMI gain in adolescents.
Observational study in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04027608 (Sensitization of the Reinforcing Value of Food as a Predictor of Weight Change in Adolescents), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sensitization of the Reinforcing Value of Food as a Predictor of Weight Change in Adolescents
Who cites it
7 citing papers in PubMed.
- Leveraging recreational activities to reduce obesity-related behaviors in children from lower-income households.Appetite · 2025Article
- Using Metabolic Testing to Personalize Behavioral Obesity Treatment.Obesity science & practice · 2025Article
- The role of hyper-palatable foods in energy intake measured using mobile food photography methodology.Eating behaviors · 2025Article
- Restriction and Pressure to Eat Are Associated Cross-Sectionally, But Not Longitudinally, With BMI z-Score in a Longitudinal Cohort Study of Adolescents.Childhood obesity (Print) · 2024Article
- Review
- Article
- Reinforcing value of food, enriched home environment, and changes in percent overweight in children.Obesity (Silver Spring, Md.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesCharacterizing behavioral phenotypes that predict increased zBMI gain during adolescence could identify novel intervention targets and prevent the development of obesity. The purpose of this study was to determine if sensitization of the relative reinforcing value (RRV) of high (HED) or low energy density (LED) foods predicts adolescent weight gain trajectories. A secondary aim was to test the hypothesis that relationships between sensitization of the RRV of food and weight change are moderated by delay discounting (DD). SUBJECTS/
methodsWe conducted a prospective, longitudinal cohort study in 201 boys and girls with an average zBMI of 0.4, who began the study between the ages of 12 and 14 years and completed the study 2 years later. Participants completed five laboratory visits where the RRV of HED and LED, and DD were assessed at a baseline (visits 1, 2, and 4) and then RRV was measured again after participants consumed a portion of the same HED and LED food for 2 weeks (visits 3 and 5; order counterbalanced). Increases (>1) in the RRV from baseline to post-daily intake were categorized as "sensitization" and decreases (≤1) were categorized as "satiation." Participants returned to the laboratory for follow-up visits at 6, 15, and 24 months to have height and weight taken and to complete additional assessments.
resultsSensitization to HED food was associated with a greater zBMI change over time (β = 0.0070; p = 0.035). There was no impact of sensitization to LED food or interaction between sensitization to HED and LED food on zBMI change and no moderation of DD on the relationship between HED sensitization and zBMI change (all p > 0.05).
conclusionOur prior work showed that sensitization to HED food is cross-sectionally associated with greater zBMI. This study extends this work by demonstrating that sensitization to HED food prospectively predicts increased zBMI gain over time in adolescents without obesity. Future studies should determine if sensitization can be modified or reduced through behavioral intervention.
trial registrationClinicaltrials.gov: NCT04027608.
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