ReviewMucosal immunology2022
Redefining intestinal immunity with single-cell transcriptomics.
Review in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Deciphering the Structure-Immunomodulatory Function Relationships of Homopolysaccharides.Nutrients · 2026Review
- An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut.Cell host & microbe · 2026Article
- Gut Microbiota-Non-Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Paratuberculosis: a mucosal immunology perspective.Frontiers in immunology · 2026Review
- Spatially resolved single-cell transcriptome analysis of murineGut microbes · 2025Article
- From Microbial Switches to Metabolic Sensors: Rewiring the Gut-Brain Kynurenine Circuit.Biomedicines · 2025Review
- Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor.Immunology and cell biology · 2025Article
- Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity.Trends in immunology · 2024Review
- Single-cell profiling of the pig cecum at various developmental stages.Zoological research · 2024Article
- Single cell transcriptomic analysis of the canine duodenum in chronic inflammatory enteropathy and health.Frontiers in immunology · 2024Article
- INVADEseq to identify cell-adherent or invasive bacteria and the associated host transcriptome at single-cell-level resolution.Nature protocols · 2023Review
- Review
- Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota.Experimental & molecular medicine · 2023Review
- Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine ofOpen biology · 2023Article
- Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses.Cell host & microbe · 2023Review
- Single-Cell RNA Sequencing Reveals Roles of Fibroblasts During Intestinal Injury and Repair in Rats with Severe Acute Pancreatitis.Journal of inflammation research · 2023Article
- Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.Immune network · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal immune system represents the largest collection of immune cells in the body and is continually exposed to antigens from food and the microbiota. Here we discuss the contribution of single-cell transcriptomics in shaping our understanding of this complex system. We consider the impact on resolving early intestine development, engagement with the neighbouring microbiota, diversity of intestinal immune cells, compartmentalisation within the intestines and interactions with non-immune cells. Finally, we offer a perspective on open questions about gut immunity that evolving single-cell technologies are well placed to address.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.