Evidence map›Paper›PMID 34848556›Full record

ArticleThorax2022

A prospective longitudinal study of chronic pulmonary aspergillosis in pulmonary tuberculosis in Indonesia (APICAL).

Findra Setianingrum, Anna Rozaliyani, Robiatul Adawiyah, Ridhawati Syam, Mulyati Tugiran, Cut Yulia Indah Sari, Finny Nandipinto, Johannes Ramnath, Arief Riadi Arifin, Diah Handayani and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. A Systematic Review of Chronic Pulmonary Aspergillosis Among Patients Treated for Pulmonary Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Pooled it
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  5. Review
  6. Association of Diabetes Mellitus and Malnutrition withInfection and drug resistance · 2026
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  7. Post-tuberculosis morbidities and their associated mortality: moving from challenges to solutions.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
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  10. Molecular identification and antifungal susceptibility testing ofAfrican journal of laboratory medicine · 2025
    Article
  11. Chronic pulmonary aspergillosis in tea population of Assam.PLoS neglected tropical diseases · 2025
    Article
  12. Article
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  20. Importance ofJournal of fungi (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Findra SetianingrumDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Anna RozaliyaniDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Robiatul AdawiyahDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Ridhawati SyamDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Mulyati TugiranDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Cut Yulia Indah SariJakarta Islamic Hospital, Cempaka Putih, Jakarta, Indonesia.
Finny NandipintoPulmonary Mycosis Centre, Jakarta, Indonesia.
Johannes RamnathDepartment of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia.
Arief Riadi ArifinPulmonary Mycosis Centre, Jakarta, Indonesia.
Diah HandayaniPulmonary Mycosis Centre, Jakarta, Indonesia.
Erlina BurhanPulmonary Mycosis Centre, Jakarta, Indonesia.
Martin RumendeDepartment of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Retno WahyuningsihDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Riina Rautemaa-RichardsonManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
David W DenningManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK ddenning@manchester.ac.uk.ORCID 0000-0001-5626-2251
University of Indonesia · IDManchester Academic Health Science Centre · GBUniversitas Kristen Indonesia · IDUniversity of Manchester · GB

Funding

Department of HealthMedical Research Council MR/P017622/1
6 · The paper itself

Abstract

objectivesChronic pulmonary aspergillosis (CPA) can complicate recovery from pulmonary TB. CPA may also be misdiagnosed as bacteriologically negative TB. This study aimed to determine the incidence of CPA in patients treated for TB in Indonesia, a country with a high incidence of TB.

methodsIn this prospective, longitudinal cohort study in patients treated for pulmonary TB, clinical, radiological and laboratory findings were analysed. Sputum was collected for fungal culture and TB PCR. Patients were assessed at baseline (0-8 weeks) and at the end (5-6 months) of TB therapy. CPA diagnosis was based on symptoms (≥3 months), characteristic radiological features and positive

resultsOf the 216 patients recruited, 128 (59%) were followed up until end of TB therapy. At baseline, 91 (42%) had microbiological evidence for TB.

conclusionCPA should be considered a relatively frequent differential diagnosis in patients with possible or proven TB in Indonesia. Lack of awareness and limited access to

Indexed as

Pulmonary AspergillosisTuberculosis, PulmonaryAntibodies, FungalChronic DiseaseHumansImmunoglobulin GIndonesiaLongitudinal StudiesPersistent InfectionProspective StudiesAntibodies, FungalImmunoglobulin GAspergillus lung diseasetuberculosis

Identifiers

PMID34848556
PMCPMC9340040
OpenAlexW3189152408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.