Evidence map›Paper›PMID 34848524›Full record

ArticleBMJ open2021

A risk-adjusted and anatomically stratified cohort comparison study of open surgery, endovascular techniques and medical management for juxtarenal aortic aneurysms-the UK COMPlex AneurySm Study (UK-COMPASS): a study protocol.

Shaneel R Patel, David C Ormesher, Samuel R Smith, Kitty H F Wong, Paul Bevis, Colin D Bicknell, Jonathan R Boyle, John A Brennan, Bruce Campbell, Andrew Cook and 17 more

Abstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shaneel R PatelVascular Surgery, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.ORCID 0000-0002-4388-2619
David C OrmesherVascular Surgery, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Samuel R SmithSchool of Medicine, University of Liverpool, Liverpool, UK.
Kitty H F WongVascular Surgery, North Bristol NHS Trust, Bristol, UK.
Paul BevisVascular Surgery, North Bristol NHS Trust, Bristol, UK.
Colin D BicknellDepartment of Surgery and Cancer, Imperial College London, London, UK.
Jonathan R BoyleVascular Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
John A BrennanVascular Surgery, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Bruce CampbellVascular Surgery, Royal Devon and Exeter Hospital, Exeter, UK.
Andrew CookWessex Institute, University of Southampton, Southampton, UK.ORCID 0000-0002-6680-439X
Alastair P CrosherRadiology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Rui V DuarteLiverpool Reviews and Implementation Group, University of Liverpool, Liverpool, UK.ORCID 0000-0001-6485-7415
Murray M FlettVascular Surgery, Ninewells Hospital, Dundee, UK.
Carrol GambleLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Richard J JacksonLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Maciej T JuszczakVascular Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Ian M LoftusVascular Surgery, St George's University Hospitals NHS Foundation Trust, London, UK.
Ian M NordonVascular Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Jai V PatelInterventional Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Kellie PlattLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Eftychia-Eirini PsarelliLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Peter C RowlandsRadiology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
John V SmythVascular Surgery, Manchester University NHS Foundation Trust, Manchester, UK.
Theodoros SpachosVascular Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
Leigh TaggartLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Claire TaylorLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Srinivasa Rao VallabhaneniVascular Surgery, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK fempop@liverpool.ac.uk.ORCID 0000-0002-4362-9277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn one-third of all abdominal aortic aneurysms (AAAs), the aneurysm neck is short (juxtarenal) or shows other adverse anatomical features rendering operations more complex, hazardous and expensive. Surgical options include open surgical repair and endovascular aneurysm repair (EVAR) techniques including fenestrated EVAR, EVAR with adjuncts (chimneys/endoanchors) and off-label standard EVAR. The aim of the UK COMPlex AneurySm Study (UK-COMPASS) is to answer the research question identified by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme: 'What is the clinical and cost-effectiveness of strategies for the management of juxtarenal AAA, including fenestrated endovascular repair?' METHODS AND ANALYSIS: UK-COMPASS is a cohort study comparing clinical and cost-effectiveness of different strategies used to manage complex AAAs with stratification of physiological fitness and anatomical complexity, with statistical correction for baseline risk and indication biases. There are two data streams. First, a stream of routinely collected data from Hospital Episode Statistics and National Vascular Registry (NVR). Preoperative CT scans of all patients who underwent elective AAA repair in England between 1 November 2017 and 31 October 2019 are subjected to Corelab analysis to accurately identify and include every complex aneurysm treated. Second, a site-reported data stream regarding quality of life and treatment costs from prospectively recruited patients across England. Site recruitment also includes patients with complex aneurysms larger than 55 mm diameter in whom an operation is deferred (medical management). The primary outcome measure is perioperative all-cause mortality. Follow-up will be to a median of 5 years. ETHICS AND DISSEMINATION: The study has received full regulatory approvals from a Research Ethics Committee, the Confidentiality Advisory Group and the Health Research Authority. Data sharing agreements are in place with National Health Service Digital and the NVR. Dissemination will be via NIHR HTA reporting, peer-reviewed journals and conferences. TRIAL REGISTRATION NUMBER: ISRCTN85731188.

Indexed as

Aortic Aneurysm, AbdominalBlood Vessel Prosthesis ImplantationEndovascular ProceduresCohort StudiesHumansPostoperative ComplicationsQuality of LifeRisk FactorsState MedicineTreatment OutcomeUnited Kingdomclinical trialsprotocols & guidelinesvascular surgery

Identifiers

PMID34848524
PMCPMC8634354

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.