Evidence map›Paper›PMID 34848510›Full record

ArticleBMJ open2021

Association between multimorbidity and socioeconomic deprivation on short-term mortality among patients with diffuse large B-cell or follicular lymphoma in England: a nationwide cohort study.

Matthew James Smith, Edmund Njeru Njagi, Aurelien Belot, Clémence Leyrat, Audrey Bonaventure, Sara Benitez Majano, Bernard Rachet, Miguel Angel Luque Fernandez

Abstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew James SmithNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK Matthew.Smith1@lshtm.ac.uk.ORCID 0000-0002-8502-0056
Edmund Njeru NjagiNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Aurelien BelotNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Clémence LeyratNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Audrey BonaventureEpidemiology of Childhood and Adolescent Cancers Team, University of Paris, Paris, France.
Sara Benitez MajanoNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Bernard RachetNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-5837-7773
Miguel Angel Luque FernandezNon-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-6683-5164

Funding

Cancer Research UK 18525Cancer Research UK 29018Cancer Research UK C7923/A18525Medical Research Council MR/T032448/1
6 · The paper itself

Abstract

objectivesWe aimed to assess the association between multimorbidity and deprivation on short-term mortality among patients with diffuse large B-cell (DLBCL) and follicular lymphoma (FL) in England.

settingThe association of multimorbidity and socioeconomic deprivation on survival among patients diagnosed with DLBCL and FL in England between 2005 and 2013. We linked the English population-based cancer registry with electronic health records databases and estimated adjusted mortality rate ratios by multimorbidity and deprivation status. Using flexible hazard-based regression models, we computed DLBCL and FL standardised mortality risk by deprivation and multimorbidity at 1 year.

resultsOverall, 41 422 patients aged 45-99 years were diagnosed with DLBCL or FL in England during 2005-2015. Most deprived patients with FL with multimorbidities had three times higher hazard of 1-year mortality (HR: 3.3, CI 2.48 to 4.28, p<0.001) than least deprived patients without comorbidity; among DLBCL, there was approximately twice the hazard (HR: 1.9, CI 1.70 to 2.07, p<0.001).

conclusionsMultimorbidity, deprivation and their combination are strong and independent predictors of an increased short-term mortality risk among patients with DLBCL and FL in England. Public health measures targeting the reduction of multimorbidity among most deprived patients with DLBCL and FL are needed to reduce the short-term mortality gap.

Indexed as

Lymphoma, FollicularLymphoma, Large B-Cell, DiffuseCohort StudiesHumansMultimorbiditySocioeconomic Factorsepidemiologylymphomastatistics & research methods

Identifiers

PMID34848510
PMCPMC8634234

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