Evidence map›Paper›PMID 34848501›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2021

COVID-19 Infection in Fingolimod- or Siponimod-Treated Patients: Case Series.

Roseanne Sullivan, Ajay Kilaru, Bernhard Hemmer, Bruce Anthony Campbell Cree, Benjamin M Greenberg, Uma Kundu, Thomas Hach, Virginia DeLasHeras, Brian J Ward, Joseph Berger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  14. Article
  15. Multiple Sclerosis Management During the COVID-19 Pandemic.Current neurology and neuroscience reports · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 5 countries.

Roseanne SullivanFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. roseanne.sullivan@novartis.com.ORCID 0000-0001-6025-465X
Ajay KilaruFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Bernhard HemmerFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-5985-6784
Bruce Anthony Campbell CreeFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Benjamin M GreenbergFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Uma KunduFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Thomas HachFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Virginia DeLasHerasFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Brian J WardFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Joseph BergerFrom the Novartis Pharmaceuticals Corporation (R.S.), East Hanover, NJ; Novartis Pharma AG (A.K., T.H., V.D.), Basel, Switzerland; Department of Neurology, Technical University of Munich, and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany; Weill Institute for Neurosciences (B.A.C.C.), Department of Neurology, University of California San Francisco, CA; Department of Neurology (B.M.G.), University of Texas Southwestern, Dallas, TX; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; Department of Medicine (B.J.W.), Division of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Canada; and Department of Neurology (J.B.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Novartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesA descriptive analysis of COVID-19 infection in patients with multiple sclerosis (MS) receiving fingolimod or siponimod.

methodsWe reviewed the cases of COVID-19 from postmarketing or ongoing clinical trials reported to Novartis through December 27, 2020.

resultsAs of December 27, 2020, 283 cases had been reported in fingolimod-treated patients. The mean age was 44 years (from n = 224; range 11-69 years), and 190 were women. Of 161 cases with available information, 138 were asymptomatic (6), mild (100), or moderate (32); 50 cases required hospitalization. At the last follow-up, 140 patients were reported as recovered/recovering, condition was unchanged in 22, and deteriorated in 3 patients; 4 patients had a fatal outcome. Information was not available for 114 patients. Of the 54 cases of COVID-19 reported in siponimod-treated patients, 45 were from the postmarketing setting and 9 from an ongoing open-label clinical trial. The mean age was 54 years (from n = 45; range 31-70), and 30 were women. Of 28 cases with available information, 24 were asymptomatic (2), mild (17), or moderate (5); 9 cases required hospitalization. At the last follow-up, 27 patients were reported as recovered/recovering, condition remained unchanged for 1, and 3 patients had a fatal outcome. Information was not available for 23 patients. DISCUSSION: Based on a review of available information, the risk of more severe COVID-19 in patients receiving fingolimod or siponimod seems to be similar to that reported in the general population and the MS population with COVID-19. However, limitations of spontaneous reporting, especially missing data, should be considered in the interpretation of these observations.

Indexed as

AdolescentAdultAgedAzetidinesBenzyl CompoundsChildClinical Trials as TopicComorbidityCOVID-19FemaleFingolimod HydrochlorideFollow-Up StudiesHumansImmunosuppressive AgentsMaleMiddle AgedAzetidinesBenzyl CompoundsFingolimod HydrochlorideImmunosuppressive Agentssiponimod

Identifiers

PMID34848501
PMCPMC8860466
OpenAlexW3215557511

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.