Evidence map›Paper›PMID 34848498›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Preservation of Eye Movements in Parkinson's Disease Is Stimulus- and Task-Specific.

Jolande Fooken, Pooja Patel, Christina B Jones, Martin J McKeown, Miriam Spering

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  17. Slowing of Movements in Healthy Aging as a Rational Economic Response to an Elevated Effort Landscape.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Reflexive eye saccadic parameters in Parkinson's disease.Frontiers in medical technology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jolande FookenCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada K7L 3N6 jolande.fooken@queensu.ca.
Pooja PatelOphthalmology & Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Christina B JonesMedicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5.
Martin J McKeownGraduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Miriam SperingOphthalmology & Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disease that includes motor impairments, such as tremor, bradykinesia, and postural instability. Although eye movement deficits are commonly found in saccade and pursuit tasks, preservation of oculomotor function has also been reported. Here we investigate specific task and stimulus conditions under which oculomotor function in PD is preserved. Sixteen PD patients and 18 healthy, age-matched controls completed a battery of movement tasks that included stationary or moving targets eliciting reactive or deliberate eye movements: pro-saccades, anti-saccades, visually guided pursuit, and rapid go/no-go manual interception. Compared with controls, patients demonstrated systematic impairments in tasks with stationary targets: pro-saccades were hypometric and anti-saccades were incorrectly initiated toward the cued target in ∼35% of trials compared with 14% errors in controls. In patients, task errors were linked to short latency saccades, indicating abnormalities in inhibitory control. However, patients' eye movements in response to dynamic targets were relatively preserved. PD patients were able to track and predict a disappearing moving target and make quick go/no-go decisions as accurately as controls. Patients' interceptive hand movements were slower on average but initiated earlier, indicating adaptive processes to compensate for motor slowing. We conclude that PD patients demonstrate stimulus and task dependency of oculomotor impairments, and we propose that preservation of eye and hand movement function in PD is linked to a separate functional pathway through the superior colliculus-brainstem loop that bypasses the fronto-basal ganglia network. Our results demonstrate that studying oculomotor and hand movement function in PD can support disease diagnosis and further our understanding of disease progression and dynamics.

Indexed as

AdultAgedAged, 80 and overEye MovementsFemaleHumansMaleMiddle AgedParkinson DiseasePhotic StimulationPsychomotor PerformanceReaction Timeeye movementsParkinson's diseasepredictionpreservation of functionsaccadessmooth pursuit

Identifiers

PMID34848498
PMCPMC8802919
OpenAlexW3215987882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.