Evidence map›Paper›PMID 34848439›Full record

SynthesisBMJ global health2021

Growth patterns by sex and age among under-5 children from 87 low-income and middle-income countries.

Janaína Calu Costa, Cauane Blumenberg, Cesar Victora

Abstract readMeta-Analysis
In one paragraph

Synthesis in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Janaína Calu CostaInternational Center for Equity in Health, Federal University of Pelotas, Pelotas, RS, Brazil calu.janaina@gmail.com.ORCID 0000-0002-7912-8685
Cauane BlumenbergInternational Center for Equity in Health, Federal University of Pelotas, Pelotas, RS, Brazil.ORCID 0000-0002-4580-3849
Cesar VictoraInternational Center for Equity in Health, Federal University of Pelotas, Pelotas, RS, Brazil.ORCID 0000-0002-2465-2180

Funding

Wellcome TrustWellcome Trust 101815/Z/13/Z
6 · The paper itself

Abstract

introductionAlthough boys tend to be more affected by linear growth faltering than girls, little is known about sex differences across distinct age groups. We aimed to compare sex differences in linear growth throughout the first 5 years of life among children from low-income and middle-income countries.

methodsWe analysed 87 cross-sectional Demographic and Health Surveys and Multiple Cluster Indicator Surveys (2010-2019). Growth was expressed as height-for-age z-scores (HAZ) based on the 2006 WHO Growth Standards. Sex-specific means were estimated for each country and results were pooled through random-effects meta-analysis for all children and by 12-month age groups. Using linear regression, we assessed the association between sex differences in HAZ and gross domestic product as a proxy for national economic development.

resultsBoys presented lower mean HAZ than girls in the first 30 months. Sex differences were mostly absent between 30 and 45 months, and in several countries, girls had lower HAZ at ages over 45 months. The pooled sex difference (boys minus girls) for the whole sample was -0.10 (95% CI -0.12 to -0.08). The difference was -0.17 (95% CI -0.20 to -0.14) at 0-11 months and -0.22 (95% CI -0.25 to -0.19) at 12-23 months. This was followed by a narrowing of the sex gap to -0.10 (95% CI -0.13 to -0.07) and -0.04 (95% CI -0.07 to -0.01) among children aged 24-35 and 36-47 months, respectively. At 48-59 months, there was evidence of female disadvantage; the mean height-for-age of boys was 0.02 (95% CI 0.00 to 0.05) SDs higher than for girls. Ecological analyses showed that in all age groups, male disadvantage decreased with increasing national income, and this was no longer present for the 4-year-old children, particularly in wealthier countries.

conclusionMale disadvantage in linear growth is most evident in the first years, but by the age of 4 years, the sex gap has mostly disappeared, and in some countries, the gap has been reversed.

Indexed as

Developing CountriesIncomeBody HeightChild, PreschoolCross-Sectional StudiesFemaleHumansMalePovertyage groupshealth surveysnutritional statussex differencessocioeconomic factors

Identifiers

PMID34848439
PMCPMC8634205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.