Evidence map›Paper›PMID 34848207›Full record

ArticleEnvironmental research2022

Association between prenatal metal exposure and adverse respiratory symptoms in childhood.

Nia McRae, Chris Gennings, Nadya Rivera Rivera, Marcela Tamayo-Ortiz, Ivan Pantic, Chitra Amarasiriwardena, Lourdes Schnaas, Rosalind Wright, Martha M Tellez-Rojo, Robert O Wright and 1 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  9. Association between PMFrontiers in public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Nia McRaeDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chris GenningsDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nadya Rivera RiveraDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marcela Tamayo-OrtizOccupational Health Research Unit, Mexican Institute of Social Security (IMSS), Mexico City, Mexico.
Ivan PanticDepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
Chitra AmarasiriwardenaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lourdes SchnaasDepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
Rosalind WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Kravis Children's Hospital, Department of Pediatrics, Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Martha M Tellez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maria José RosaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: maria.rosa@mssm.edu.
Icahn School of Medicine at Mount Sinai · USInstituto Nacional de Perinatología · MXMount Sinai Hospital · USInstituto Nacional de Salud Pública · MXMexican Social Security Institute · MX

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortR24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton, Maria Jose Rosa · 2017 to 2026
$1.8M
Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican ChildrenR00ES027496 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROSA, MARIA JOSE · 2019 to 2021
$743k
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES027496NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R24 ES028522
6 · The paper itself

Abstract

introductionManganese and lead have been cross-sectionally associated with adverse respiratory outcomes in childhood but there is limited data on their combined effects starting in utero. We examined associations between in utero exposure to metals and childhood respiratory symptoms.

methodsWe assessed 633 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) birth cohort in Mexico City. Blood manganese (BMn) and lead (BPb) were measured in mothers at 2

resultsIn adjusted models, higher 2

conclusionPrenatal exposure to Pb was associated with higher odds of ever wheeze while Mn was negatively associated with odds of current wheeze. These findings underscore the need to consider prenatal metal exposure, including low exposure levels, in the study of adverse respiratory outcomes.

Indexed as

AsthmaHypersensitivityPrenatal Exposure Delayed EffectsTobacco Smoke PollutionFemaleHumansPregnancyRespiratory SoundsTobacco Smoke PollutionLeadManganeseMetalsPrenatal exposureRespiratoryWheeze

Identifiers

PMID34848207
PMCPMC8768059
OpenAlexW3215409920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.