Evidence map›Paper›PMID 34847948›Full record

ArticleCardio-oncology (London, England)2021

Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience.

Alessandra Vecchié, Georgia Thomas, Edoardo Bressi, Aldo Bonaventura, Justin M Canada, David Chuquin, Dinesh Kadariya, Usman Piracha, Delia Endicott, Roshanak Markley and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Unmasking orthostatic hypotension after cellular therapy: risk factors, implications, and clinical significance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Alessandra VecchiéVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA. antonio.abbate@vcuhealth.org.
Georgia ThomasVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Edoardo BressiVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Aldo BonaventuraVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Justin M CanadaVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
David ChuquinVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Dinesh KadariyaVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Usman PirachaVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Delia EndicottVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Roshanak MarkleyVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Amir ToorMassey Cancer Center, Virginia Commonwealth University, Richmond, USA.
Michael HessVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.
Antonio AbbateVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E. Broad Street, Box 980204, Richmond, VA, 23298, USA.ORCID http://orcid.org/0000-0002-1930-785X
Virginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for hematologic cancers. HCT survivors are at risk of developing long-term complications impacting on morbidity and mortality. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been anecdotally described after HCT. However, the incidence and clinical characteristics of patients with OH and POTS after HCT has not been well defined.

methodsThis retrospective study included 132 patients who had HCT between March 2011 and July 2018 and were referred to Cardio-oncology clinic. Patients were screened for OH and POTS. Using logistic regression analysis we evaluated the association between clinical factors and the incidence of OH and POTS.

resultsMedian age was 58 (47-63) years, 87 (66%) patients were male, 95 (72%) were Caucasian. OH was diagnosed in 30 (23%) subjects and POTS in 12 (9%) after the HCT. No significant differences in demographic characteristics were found when comparing patients with and without OH or POTS. The two groups did not differ for cardiovascular diseases prevalence nor for the prior use of antihypertensive drugs. Previous radiotherapy and treatment with specific chemotherapy drugs were found to be associated with the incidence of OH or POTS, but none of the factors maintained the significance in the multivariate model. Pharmacological therapy was required in 38 (91%) cases, including a b-adrenergic blocker (n = 24, 57%), midodrine (n = 24, 57%) and fludrocortisone (n = 7, 18%).

conclusionOrthostatic intolerance syndromes are commonly diagnosed in patients referred to the cardiologist after HCT, involving approximately 1/3 of patients and requiring pharmacological therapy to cope with symptoms in the majority of cases. Risk factors specific to this population are identified but cannot fully explain the incidence of POTS and OH after HCT.

Indexed as

Bone marrow transplantChemotherapyDysautonomiaOrthostatic hypotensionPostural tachycardia syndrome

Identifiers

PMID34847948
PMCPMC8630909
OpenAlexW3215455656

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.