Evidence map›Paper›PMID 34847896›Full record

ReviewBMC pediatrics2021

Primary breast lymphoma of childhood: a case report and review of literature.

Giulia A Restivo, Marta Pillon, Lara Mussolin, Clara Mosa, Angela Guarina, Angela Trizzino, Salvatore Ialuna, Elisa Carraro, Emanuele S G D'Amore, Giovanna Russo and 5 more

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Primary breast lymphoma: A rare case report.International journal of surgery case reports · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Giulia A RestivoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.
Marta PillonClinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Lara MussolinClinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Clara MosaDepartment of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
Angela GuarinaDepartment of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
Angela TrizzinoDepartment of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
Salvatore IalunaNuclear Medicine Unit, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
Elisa CarraroClinic of Pediatric Hemato-Oncology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Emanuele S G D'AmoreDepartment of Pathology, San Bortolo Hospital, Vicenza, Italy.
Giovanna RussoPediatric Hematology and Oncology Unit - AOU Policlinico "Rodolico-San Marco", University of Catania, Catania, Italy. diberuss@unict.it.ORCID 0000-0001-9369-7473
Caterina EliaAYA Oncology and Pediatric Radiotherapy Unit, CRO - Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy.
Maurizio MascarinAYA Oncology and Pediatric Radiotherapy Unit, CRO - Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy.
Adriana ZangaraRadiology Unit, Radiology Department, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, Palermo, Italy.
Paolo D'AngeloDepartment of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
Piero FarruggiaDepartment of Pediatric Hemato-Oncology, ARNAS Ospedali Civico, G. Di Cristina, Palermo, Italy.
Azienda di Rilievo Nazionale ed Alta Specializzazione · ITUniversity of Padua · ITCentro di Riferimento Oncologico · ITOspedale San Bortolo · ITOspedale Vincenzo Cervello · ITUniversity of Catania · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. CASE PRESENTATION: We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy.

conclusionsOur case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.

Indexed as

Breast NeoplasmsLymphoma, Large B-Cell, DiffuseAdolescentAntineoplastic Combined Chemotherapy ProtocolsChildFemaleHumansRemission InductionRituximabRituximabChildrenPrimary breast lymphomarituximab

Identifiers

PMID34847896
PMCPMC8630920
OpenAlexW3215737487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.