Evidence map›Paper›PMID 34847776›Full record

ReviewOpen biology2021

Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system.

Meng-Hsuan Wen, Xihong Xie, Pei-San Huang, Karen Yang, Tai-Yen Chen

Open access · goldAbstract readReview
In one paragraph

Review in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The interactions of copper, glutamate, and cuproptosis: insights into brain health and Alzheimer's disease pathology.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  5. Article
  6. Metal-Dependent Cell Death in Renal Fibrosis: Now and in the Future.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. [Lead exposure aggravates AβNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Copper Modulates Adult Neurogenesis in Brain Subventricular Zone.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Meng-Hsuan WenDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0003-2043-460X
Xihong XieDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.
Pei-San HuangDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.
Karen YangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Tai-Yen ChenDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-2881-3068
University of Houston · USPrinceton University · US

Funding

Quantitative Cu-Homeostasis in Live Mammalian Cells at the Single-Molecule LevelR35GM133505 · NIGMS · UNIVERSITY OF HOUSTON · PI CHEN, TAI-YEN · 2019 to 2023
$2.1M
NIGMS NIH HHS R35 GM133505
6 · The paper itself

Abstract

Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases. Accumulating evidence from biophysical, cellular and

Indexed as

AnimalsCopperCopper Transport ProteinsGene Expression RegulationHomeostasisHumansNervous SystemNervous System DiseasesParkinson DiseaseSignal TransductionCopperCopper Transport ProteinsATP7A/Bcopper transportersCTR1membrane trafficking regulatorsneurodegenerative diseases

Identifiers

PMID34847776
PMCPMC8633785
OpenAlexW3215925373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.