ArticleNature2022
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 1 pooled it
24.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 1 synthesis or guideline pooled it, 237 citations in OpenAlex.
- Immune checkpoint inhibitor- and phosphatidylinositol-3-kinase inhibitor-related diabetes induced by antineoplastic drugs: two case reports and a literature review.Frontiers in endocrinology · 2023Pooled it
- Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial.Signal transduction and targeted therapy · 2026Trial
- Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes.The Journal of clinical investigation · 2024Trial
- The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment.Oncoimmunology · 2026Article
- The β-cells in type 1 diabetes mellitus: findings from human pancreas studies.Nature reviews. Endocrinology · 2026Review
- Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis.Clinical reviews in allergy & immunology · 2026Review
- Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes.The Journal of clinical investigation · 2026Article
- Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes.The Journal of clinical investigation · 2026Article
- Single cell multi-omics guided hydrogel enables closed-loop therapy for renal osteodystrophy.Nature communications · 2026Article
- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
- Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways.Experimental & molecular medicine · 2026Article
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Type 1 Diabetes Driven by Residual Recipient T Cells After Hematopoietic Cell Transplantation: A Case Report.Diabetes care · 2026Article
- Hybrid Insulin Peptides as Antigens and Tolerogens for Pathogenic T Cells in Autoimmune Diabetes.Immunological reviews · 2026Review
- CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetes.bioRxiv : the preprint server for biology · 2026Article
- Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata.Nature metabolism · 2026Article
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes.iScience · 2026Article
- Article
- Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Sofia V GeartyImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8633-3663
Friederike DündarDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2301-112X
Paul ZumboDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Gabriel Espinosa-CarrascoImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mojdeh ShakibaImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Francisco J Sanchez-RiveraCancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nicholas D SocciBioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Prerak TrivediImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scott W LoweCancer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5284-9650
Peter LauerAduro Biotech, Berkeley, CA, USA.
Neeman MohibullahIntegrated Genomics Operation Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Agnes VialeIntegrated Genomics Operation Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Teresa P DiLorenzoDepartment of Microbiology and Immunology & Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA. dob2014@med.cornell.edu.ORCID http://orcid.org/0000-0002-8006-7752
Andrea SchietingerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. schietia@mskcc.org.ORCID http://orcid.org/0000-0003-3644-1687
Memorial Sloan Kettering Cancer Center · USCornell University · USAduro BioTech (United States) · USAlbert Einstein College of Medicine · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MViral Immunoregulatory Genes in Beta Cells to Treat DiabetesP01DK052956 · NIDDK · YESHIVA UNIVERSITY · PI FLEISCHER, NORMAN S. · 1998 to 2007
$8.5MStructural, functional, and mechanistic anlaysis of autoreactive CD8 T cellsR01AI123730 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C., DILORENZO, TERESA P · 2018 to 2022
$3.6MSpatiotemporal regulation of T cell fate decisions in cancerDP2CA225212 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SCHIETINGER, ANDREA · 2017 to 2017
$2.6MTranslational Research in Oncology Training ProgramT32CA160001 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SAWYERS, CHARLES L. · 2011 to 2020
$2.0MT cell Heterogeneity and Fate Diversification in Autoimmune Type I DiabetesF30DK122691 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI GEARTY, SOFIA VACCARINO · 2019 to 2022
$190kNCI NIH HHS DP2 CA225212NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA160001NIAID NIH HHS R01 AI123730NIDDK NIH HHS F30 DK122691NIDDK NIH HHS P01 DK052956NIDDK NIH HHS P30 DK020541NIGMS NIH HHS T32 GM007739
Abstract
CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance mechanisms in autoreactive CD8 T cells
Indexed as
AnimalsCD8-Positive T-LymphocytesCell Self RenewalClone CellsDiabetes Mellitus, Type 1Disease Models, AnimalFemaleGlucose-6-PhosphataseHepatocyte Nuclear Factor 1-alphaInsulin-Secreting CellsLymph NodesMaleMiceReceptors, Antigen, T-CellSingle-Cell AnalysisStem CellsG6pc2 protein, mouseGlucose-6-PhosphataseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.