Evidence map›Paper›PMID 34847524›Full record

ReviewCurrent opinion in microbiology2022

Cooperative defenses during enteropathogenic infection.

Katia Troha, Janelle S Ayres

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  6. Article
  7. Crystal Structure of an SSB Protein fromInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katia TrohaMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Janelle S AyresMolecular and Systems Physiology Lab, Gene Expression Lab, Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: jayres@salk.edu.

Funding

Host-microbe interactions: Harnessing co-evolution to treat diseaseDP1AI144249 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2018 to 2022
$6.7M
Tolerance defenses in host-microbiota interactionsR01AI114929 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2015 to 2025
$4.9M
NIAID NIH HHS DP1 AI144249NIAID NIH HHS R01 AI114929
6 · The paper itself

Abstract

During their co-evolution with pathogens, hosts acquired defensive health strategies that allow them to maintain their health or promote recovery when challenged with infections. The cooperative defense system is a largely unexplored branch of these evolved defense strategies. Cooperative defenses limit physiological damage and promote health without having a negative impact on a pathogen's ability to survive and replicate within the host. Here, we review recent discoveries in the new field of cooperative defenses using the model pathogens Citrobacter rodentium and Salmonella enterica. We discuss not only host-encoded but also pathogen-encoded mechanisms of cooperative defenses. Cooperative defenses remain an untapped resource in clinical medicine. With a global pandemic exacerbated by a lack of vaccine access and a worldwide rise in antibiotic resistance, the study of cooperative defenses offers an opportunity to safeguard health in the face of pathogenic infection.

Indexed as

Enterobacteriaceae InfectionsSalmonella entericaCitrobacter rodentiumHealth PromotionHost-Pathogen InteractionsHumans

Identifiers

PMID34847524
PMCPMC8818259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.